| 利培酮合并氟西汀对无精神病性症状抑郁症的疗效比较 |
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| 引用本文： | 钱建军,何炳福,石永扬,高赛男,金海龙.利培酮合并氟西汀对无精神病性症状抑郁症的疗效比较[J].中国临床药学杂志,2008,17(5). |
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| 作者姓名： | 钱建军 何炳福 石永扬 高赛男 金海龙 |
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| 作者单位： | 绍兴市第七人民院心理科,绍兴,312000 |
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| 摘 要： | 目的 观察利培酮合并氟西汀对无精神病性症状抑郁症的疗效和安全性.方法 147例无精神病性症状抑郁症患者随机分为研究组(利培酮 氟西汀)72例、对照组(氟西汀)75例,治疗8wk.于治疗前、治疗后每2 wk测评汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、治疗中需处理的不良反应量表(TESS).疗效评价以HAMD减分率为标准,不良反应以TESS评分为标准.结果 2组HAMD、HAMA评分组间比较从wk2末开始差异有统计学意义(P＜0.05),2组疗效比较差异有统计学意义(P＜0.05),各时期TESS评分组间比较差异无统计学意义(P＞0.05).结论 利培酮合并氟西汀治疗无精神病性症状抑郁症的疗效和安全性较好.
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| 关 键 词： | 无精神病性症状抑郁症 利培酮 氟西汀 |
Comparison of risperidone combined with fluoxetine in treatment of depression without psychotic symptoms |
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| QIAN Jianjun,HE Bingfu,SHI Yongyang,GAO Sainan,JIN Hailong.Comparison of risperidone combined with fluoxetine in treatment of depression without psychotic symptoms[J].Chinese Journal of Clinical Pharmacy,2008,17(5). |
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| Authors: | QIAN Jianjun HE Bingfu SHI Yongyang GAO Sainan JIN Hailong |
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| Institution: | QIAN Jianjun HE Bingfu SHI Yongyang GAO Sainan JIN Hailong (Department of Psychology,Shaoxing Seventh People\'s Hospital,Shaoxing 312000,China) |
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| Abstract: | AIM To compare the efficacy and adverse drug reaction(ADR)of risperidone combined with fluoxe- tine in patients with depression without psychotic symptoms.METHODS One handred and forty-seven patients with de- pression without psychotic symptoms were randomly divided into study group(risperidone+fluoxetine,n=72)and control group(fluoxetine,n=75)and observed for 8 weeks.All patients were assessed with HAMD,HAMA and TESS.The therapeutic effect was assessed using subtraction rates of HAMD,and drug-related ADR w... |
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| Keywords: | depression without psychotic symptom risperidone fluoxetine |
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