川崎病热程与冠状动脉病变发生率关系分析

目的探讨川崎病热程与冠状动脉病变发生率的关系。方法回顾性分析1997年1月-2007年12月期间352例住院川崎病患儿中不同类型川崎病热程与冠状动脉病变发生率的关系；将不同热程的川崎病病例冠状动脉病变发生率用线性趋势图表示，采用Cochran-Armitage趋势检验分析。结果352例川崎病患儿中有冠状动脉病变88例。其中典型川崎病294例，有冠状动脉病变68例；不典型川崎病58例，有冠状动脉病变20例；静脉注射免疫球蛋白（IVIG）治疗无反应川崎病44例，有冠状动脉病变18例。线性趋势图分析显示，所有352例川崎病和294例典型川崎病的热程与冠状动脉病变发生率呈正相关趋势（P〈0．05），而不完全性川崎病、IVIG治疗无反应川崎病的热程与冠状动脉病变发生率虽有正相关趋势，但差异无统计学意义。结论小儿川崎病发热时间越长，冠状动脉病变发生的风险越高。

Relationship between Duration of Fever and Incidence of Coronary Artery Lesion in Patients with Kawasaki Disease

Objective To provide evidence for timely diagnosis and treatment of Kawasaki disease through assessing the relationship between the duration of fever and the incidence of coronary artery lesion in patients with Kawasaki disease.Methods To retrospectively analyze the clinical information of 352 inpatients with Kawasaki disease(including typical Kawasaki disease,incomplete Kawasaki disease,and non-responsive to intravenous immunoglobulin treatment Kawasaki disease)from January 1997 to December 2007.The relationship between the duration of fever and the incidence of coronary artery lesion was presented by a linear trend plot,using Cochran-Armitage trend test.A value of P < 0.05 was considered statistically significant.Results Among 352 patients with Kawasaki disease,88 had coronary artery lesions.Sixty-eight out of 294 patients with typical Kawasaki disease,20 out of 58 patients with incomplete Kawasaki disease,and 18 out of 44 patients with non-responsive Kawasaki disease had coronary artery lesions.Linear trend analysis showed that the duration of fever in all 352 patients with Kawasaki disease and 294 cases with typical Kawasaki disease was positively correlated with the incidence of coronary artery lesion(P<0.05).However,in patients with incomplete Kawasaki disease and non-responsive Kawasaki disease,the relationship between the duration of fever and the incidence of coronary artery lesion was not significant(P> 0.05).Conclusion The longer the duration of fever was in patients with Kawasaki disease,higher the risk of coronary artery lesion.