| 四妙散加味对膝关节滑膜炎湿热阻络证患者关节液炎性因子和神经肽物质的影响 |
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| 引用本文： | 胡华,李连泰,刘艳伟,王书君,谢双喜,孙建君.四妙散加味对膝关节滑膜炎湿热阻络证患者关节液炎性因子和神经肽物质的影响[J].中国实验方剂学杂志,2020,26(6):97-102. |
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| 作者姓名： | 胡华 李连泰 刘艳伟 王书君 谢双喜 孙建君 |
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| 作者单位： | 承德医学院 附属医院, 河北 承德 067000,承德医学院 附属医院, 河北 承德 067000,承德医学院 附属医院, 河北 承德 067000,承德医学院 附属医院, 河北 承德 067000,承德医学院 附属医院, 河北 承德 067000,承德医学院 附属医院, 河北 承德 067000 |
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| 基金项目： | 河北省中医药管理局科研计划项目（2016066） |
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| 摘 要： | 目的:观察四妙散加味对膝关节滑膜炎(KS)湿热阻络证的临床疗效及对关节液炎性因子和神经肽物质的影响。方法:将135例患者分为对照组67例和观察组68例。对照组抽净关节内积液后,以曲安奈德注射液关节内注射,1周1次,共2次,并口服醋氯芬酸缓释片,0. 2 g/次,1次/d。观察组西医治疗措施同对照组,并内服四妙散加味,1剂/d,两组疗程均为连续治疗4周。进行治疗前后膝关节疼痛和肿胀程度评分,膝关节功能采用美国西安大略和麦克马斯特大学骨关节炎评分(WOMAC),进行治疗前后湿热阻络证和膝关节局部体征评价;检测治疗前后关节液白细胞介素-1β(IL-1β),IL-6,肿瘤坏死因子-α(TNF-α),超敏C反应蛋白(hs-CRP),P物质(SP),钙素基因相关肽(CGRP),神经肽Y(NPY)和血管活性肠肽(VIP)水平。结果:治疗后观察组膝关节疼痛程度和肿胀程度均低于对照组(P 0. 01);观察组WOMAC量表各因子评分和总分均低于对照组(P 0. 01);观察组湿热阻络证积分、膝关节屈伸范围评分和浮髌试验评分均低于对照组(P 0. 01);观察组关节液IL-1β,IL-6,TNF-α和hs-CRP水平均低于对照组(P 0. 01);观察组关节液SP,CGRP,NPY和VIP水平均低于对照组(P 0. 01);经秩和检验,观察组临床疗效优于对照组(Z=2. 089,P 0. 05)。结论:四妙散加味治疗KS湿热阻络证患者,能明显减轻疼痛、肿胀症状,促进膝关节活动功能恢复,并能抑制关节液中促炎因子和神经肽类物质表达,提高了临床治疗效果。
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| 关 键 词： | 膝关节滑膜炎 湿热阻络证 四妙散 炎性因子 神经肽物质 |
| 收稿时间： | 2019/8/7 0:00:00 |
Effect of Modified Simiaosan on Inflammatory Factors and Neuropeptide Substances of Patients with Synovitis of Knee Joint and Damp-heat Obstruction Collateral Syndrome |
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| HU Hu,LI Lian-tai,LIU Yan-wei,WANG Shu-jun,XIE Shuang-xi and SUN Jian-jun.Effect of Modified Simiaosan on Inflammatory Factors and Neuropeptide Substances of Patients with Synovitis of Knee Joint and Damp-heat Obstruction Collateral Syndrome[J].China Journal of Experimental Traditional Medical Formulae,2020,26(6):97-102. |
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| Authors: | HU Hu LI Lian-tai LIU Yan-wei WANG Shu-jun XIE Shuang-xi and SUN Jian-jun |
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| Institution: | The Affiliated Hospital of Chengde Medical College, Chengde 067000, China,The Affiliated Hospital of Chengde Medical College, Chengde 067000, China,The Affiliated Hospital of Chengde Medical College, Chengde 067000, China,The Affiliated Hospital of Chengde Medical College, Chengde 067000, China,The Affiliated Hospital of Chengde Medical College, Chengde 067000, China and The Affiliated Hospital of Chengde Medical College, Chengde 067000, China |
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| Abstract: | |
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| Keywords: | knee synovitis damp-heat obstruction collateral syndrome Simiaosan inflammatory factors neuropeptide substances |
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