| 广州管圆线虫感染致病机制的研究进展 |
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| 引用本文： | 廖瑶,孙希,吴忠道.广州管圆线虫感染致病机制的研究进展[J].中国血吸虫病防治杂志,2019,31(1):98-102. |
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| 作者姓名： | 廖瑶 孙希 吴忠道 |
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| 作者单位： | 1中山大学中山医学院寄生虫学教研室（广州 510080）；2热带病防治研究教育部重点实验室 |
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| 基金项目： | 国家重点研发计划（2016YFC1200500）；中山大学青年教师培育项目（17ykpy09） |
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| 摘 要： | 广州管圆线虫病是因感染了广州管圆线虫后其幼虫移行至宿主中枢神经系统，从而引起以嗜酸性粒细胞增多为特征、以脑炎和脑膜脑炎为主要临床表现的一种危害严重的食源性寄生虫病，阐明其致病机制对于广州管圆线虫病防治具有重要意义。本文主要就广州管圆线虫感染引起嗜酸性粒细胞增多性脑炎和脑膜脑炎机制研究进展作一综述。
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| 关 键 词： | 广州管圆线虫病 嗜酸性粒细胞 致病机制 小胶质细胞 microRNA |
Advances in pathogenic mechanisms of Angiostrongylus cantonensis infection |
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| LIAO Yao,SUN Xi,WU Zhong-Dao.Advances in pathogenic mechanisms of Angiostrongylus cantonensis infection[J].Chinese Journal of Schistosomiasis Control,2019,31(1):98-102. |
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| Authors: | LIAO Yao SUN Xi WU Zhong-Dao |
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| Institution: | 1 Department of Parasitology, Zhongshan School of Medicine, Sun Yat?Sen University, Guangzhou 510080, China; 2 Key Laboratory of Tropical Diseases Control, Ministry of Education, China |
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| Abstract: | Angiostrongylosis, a food?borne parasitic disease, is caused by the migration of larvae of Angiostrongylus cantonensis to the host’s central nervous system after it is infected. It is a serious disease with eosinophilic encephalitis and meningoencephalitis as the main clinical manifestations. Understanding of its pathogenic mechanism is important for the prevention and treatment of angiostrongylosis. This paper reviews the mechanism of eosinophilic meningitis and meningoencephalitis caused by A. cantonensis infection. |
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| Keywords: | Angiostrongylus cantonensis Eosinophil Pathogenic mechanism Microglia MicroRNA |
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