完全性淋巴结清扫对前哨淋巴结阳性黑色素瘤患者的预后价值Meta分析

目的 探讨完全性淋巴结清扫对前哨淋巴结活检阳性黑色素瘤患者的预后价值。方法 计算机检索数据库PubMed、Embase、Cochrane Library、中国知网和万方，并联合参考文献追查，采用Meta分析分析患者生存状态。结果 纳入10篇符合标准的文献，Meta分析结果显示：完全性淋巴结清扫组与淋巴结观察组的肿瘤特异性生存（HR: 0.99, 95%CI: 0.86~1.14, P=0.89）、无复发生存（HR: 0.89, 95%CI: 0.72~1.08, P=0.24）和无远处转移生存（HR: 1.03, 95%CI: 0.89~1.20, P=0.71）差异无统计学意义。结论 完全性淋巴结清扫不能为前哨淋巴结活检阳性黑色素瘤患者带来生存获益。

Prognostic Value of Completion Lymph Node Dissection on Melanoma Patients with Positive Sentinel Lymph Node Biopsy: A Meta-analysis

Objective To assess the prognostic value of completion lymph node dissection on melanoma patients with positive sentinel lymph node biopsy. Methods We searched PubMed, Embase, Cochrane Library, CNKI, Wanfang and the reference trace for relevant literature. Meta-analysis was applied for patients’ survival. Results A total of 10 clinical trials were included. There was no significant difference between the completion lymph node dissection group and the lymph node observation group in melanoma specific survival (HR: 0.99, 95%CI: 0.86-1.14, P=0.89), recurrence-free survival (HR: 0.89, 95%CI: 0.72-1.08, P=0.24) or distant metastasis-free survival (HR: 1.03, 95%CI: 0.89-1.20, P=0.71). Conclusion Completion lymph node dissection could not benefit the survival of melanoma patients with positive sentinel lymph node biopsy.