肠道菌群与子宫肌瘤的相关性分析

目的分析女性子宫肌瘤、正常女性肠道中菌群水平,探讨肠道菌群与子宫肌瘤发生的相关性。方法选取2015年6月至2017年7月海南省妇幼保健院收治的70例女性子宫肌瘤为研究对象,同时选取70例正常体检女性作为对照组,收集两组受检者的粪便,提取其DNA并测定其肠道菌群的数量,比较两组受检者肠道各个菌群水平,并分析肠道菌群与子宫肌瘤发生的相关性。结果子宫肌瘤组患者细菌总数、乳酸杆菌水平均明显高于对照组,两者比较差异有统计学意义(P<0.05);双歧杆菌、拟杆菌、梭杆菌和变形杆菌水平均明显低于对照组,两者比较差异有统计学意义(P<0.05)。细菌总数、双歧杆菌和乳酸杆菌水平与子宫肌瘤发生呈正相关(P<0.05),拟杆菌、梭杆菌、变形杆菌水平与子宫肌瘤发生呈负相关(P<0.05)。结论肠道菌群的数量和菌种与子宫肌瘤的发生存在相关性。

Relationship Between Intestinal Microflora and Uterine Myoma

Objective To analyze the level of intestinal flora in uterine myoma patients and normal women, and to explore the correlation between intestinal flora and uterine myoma. Methods We selected 70 female patients with uterine myoma treated in our hospital from June 2015 to July 2017 as the study subjects, and 70 healthy women as control group. The feces of two groups were collected to extract their DNA and measure the number of intestinal flora. The levels of intestinal microflora were compared between the two groups, and the correlation between intestinal flora and the occurrence of uterine myoma was analyzed. Results Compared with the control group, total bacterial count and lactobacillus levels were significantly higher, and the levels of bifidobacterium, bacteroidetes, fusobacterium and proteus species were significantly lower in uterine myoma group (all P<0.05). Total number of bacteria, bifidobacterium and lactobacillus were positively correlated, while bacteroides, clostridium and proteus were negatively correlated with the occurrence of uterine myoma (all P<0.05). Conclusion There is correlation of the number and species of intestinal flora with the occurrence of uterine myoma.