| IgG4相关性肝胆胰疾病的发病机制 |
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| 引用本文： | 张德华,赵婕.IgG4相关性肝胆胰疾病的发病机制[J].临床肝胆病杂志,2019,35(6):1401-1405. |
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| 作者姓名： | 张德华 赵婕 |
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| 作者单位： | 山西医科大学第二临床医院消化内科,太原,030001;山西医科大学第二临床医院消化内科,太原,030001 |
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| 摘 要： | IgG4相关性疾病(IgG4-RD)是一种可累及全身的多系统的慢性进行性自身免疫性疾病,IgG4相关性肝胆胰疾病为IgG4-RD受累肝胆胰腺系统表现,其主要特征为血清IgG4水平升高和IgG4阳性淋巴浆细胞浸润,可模仿各种炎症及肿瘤疾病,临床易漏诊误诊。从基因遗传、感染与分子模拟、免疫因素等方面阐述IgG4相关性肝胆胰疾病的发病机制,从而提高对该病的认识。
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| 关 键 词： | 免疫球蛋白G 自身免疫疾病 胰腺炎 胆管炎 硬化性 肝疾病 综述 |
Pathogenesis of immunoglobulin G4-related hepatobiliary and pancreatic diseases |
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| ZHANG Dehua,ZHAO Jie.Pathogenesis of immunoglobulin G4-related hepatobiliary and pancreatic diseases[J].Chinese Journal of Clinical Hepatology,2019,35(6):1401-1405. |
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| Authors: | ZHANG Dehua ZHAO Jie |
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| Institution: | (Department of Gastroenterology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China) |
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| Abstract: | Immunoglobulin G4(IgG4)-related disease is a chronic progressive autoimmune disease involving multiple systems throughout the body.IgG4-related hepatobiliary and pancreatic diseases are the manifestation of IgG4-related disease involving the hepatobiliary and pancreatic systems,with the main features of an increased serum IgG4 level and IgG4-positive lymphoplasmacytic infiltration.IgG4-related hepatobiliary and pancreatic diseases can mimic various inflammations and tumor diseases,which may lead to missed diagnosis and misdiagnosis in clinical practice.This article elaborates on the pathogenesis of IgG4-related hepatobiliary and pancreatic diseases from the perspectives of genetic inheritance,infection and molecular mimicry,and immune factors,so as to improve the understanding of such diseases. |
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| Keywords: | immunoglobulin G autoimmune diseases pancreatitis cholangitis sclerosing liver diseases review |
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