多次吡喹酮治疗抗血吸虫病肝纤维化疗效观察

目的观察多次吡喹酮治疗对抗血吸虫病肝纤维化的作用。方法选择60例血吸虫病肝纤维化患者(临床诊断病例),随机分成治疗组和对照组,每组30人。治疗组在常规护肝、对症治疗的基础上连续3年每年给予吡喹酮60 mg/kg,分2 d服完;对照组予以常规的护肝、对症治疗,2组疗程均为36个月。观察治疗前后2组患者临床症状、肝功能及血清透明质酸(HA)、层粘蛋白(LN)、4型胶原(IV-C)、Ⅲ型前胶原肽(PCIII)等肝纤维化指标的变化,并作统计分析。结果治疗组患者临床症状、肝功能及HA、LN、IV-C、PCIII水平均有不同程度下降,总有效率93%(26/28),对照组总有效率60%(16/27),两组差异有统计学意义(P0.05)。结论多次吡喹酮治疗对抗血吸虫病肝纤维化有较好的治疗效果。

Efficacy of repeated application of praziquantel in treatment of hepatic fibrosis due to schistosomiasis

Objective To evaluate the efficacy of repeated application of praziquantel in the treatment of hepatic fibrosis due to schistosomiasis. Methods A total of 60 patients with schistosomiasis hepatic fibrosis （clinically diagnosed cases） were selected and divide into a treatment group and control group randomly， with 30 cases each group. The patients in the treatment group were given praziquantel ［30 mg/（kg·d） for 2 days］ each year for three consecutive years， on the basis of the conventional liver protection therapy and symptomatic treatment. The patients in the control group were given the conventional liver protection therapy and symptomatic treatment. All the treatment duration was 36 months. The clinical symptoms were observed， and the liver function， and the levels of HA， LN， IV?C， and PCIII were detected in the two groups before and after the treatment. Results The clinical symptoms and liver function improved， and the HA， LN， IV?C， PCIII levels were decreased in the treatment group with varying degrees， and the total effective rate was 93% （26/28）. The total effective rate in the control group was 60% （16/27）. There was a significant difference between the two groups in the total effective rate （P < 0.05）. Conclusion The repeated application of praziquantel has a better therapeutic efficacy in the treatment of hepatic fibrosis due to schistosomiasis.