| HBV生物学特性与肝纤维化进展的关系 |
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| 引用本文： | 常秀娟,李因茵,杨斌,曾珍,黄加干,杨永平. HBV生物学特性与肝纤维化进展的关系[J]. 临床肝胆病杂志, 2019, 35(8): 1834-1837 |
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| 作者姓名： | 常秀娟 李因茵 杨斌 曾珍 黄加干 杨永平 |
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| 作者单位： | 解放军医学院,北京100853;解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心,北京100039;解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心,北京,100039 |
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| 摘 要： | HBV通过激发宿主免疫反应,引起肝损伤,导致肝纤维化、肝硬化、肝癌。肝纤维化进展是肝脏疾病相关死亡的关键过程,归纳了HBV基因型、HBV基因(包括基本核心启动子区/前C区、前S区、X区)变异、HBV基因剪接体、HBV RNA、HBcAg、 HBsAg 与肝纤维化进展的相关性研究。认为上述HBV生物学特性和肝纤维化进展密切相关。
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| 关 键 词： | 乙型肝炎病毒 肝硬化 基因 基因型 |
Association of biological characteristics of hepatitis B virus with the progression of liver fibrosis |
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| Affiliation: | (Chinese PLA Medical School, Beijing 100853, China) |
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| Abstract: | Hepatitis B virus (HBV) causes liver injury by stimulating host immune response and may lead to liver fibrosis, liver cirrhosis, and liver cancer. Progression of liver fibrosis is a key factor in liver disease-related death. This article summarizes the association of HBV genotype, HBV gene mutation in basic core promoter region/pre-C region, pre-S region, and X region, HBV gene splicing, HBV RNA, HBcAg, and HBsAg with the progression of liver fibrosis. It is pointed out that the above biological characteristics of HBV are closely associated with the progression of liver fibrosis. |
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| Keywords: | hepatitis B virus liver cirrhosis genes genotype |
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