肠道微生态-介导的-饮食结构对恶性肿瘤的影响

大量证据表明,植物性饮食可以显著降低多种恶性肿瘤,尤其是大肠癌的发病率,而油腻饮食和肉食则是肿瘤发病的危险因素。不同的膳食结构直接影响肠道微生物的种类,进而调节肠道微生物代谢产物的生成,从而替机体作出"促癌"或"抑癌"的选择。本文综述了近年来通过饮食因素调控肠道微生态及其代谢产物而影响恶性肿瘤发生、发展、治疗效果及预后的临床证据与机制,为恶性肿瘤的防治提供思路。

Effect of Dietary Pattern Mediated by Gut Microbiota on Malignant Tumor

A large amount of evidence suggest that vegetarian dietary pattern can significantly reduce the incidence of various malignancies, especially colorectal cancer; while high fat diet and meat are the risk factors for cancer. Different dietary structures directly affect the gut microbiota and their metabolites, thus inducing a tumor prone or tumor suppressive effect. In this article, we reviewed the influence of dietary factors on tumor occurrence, development, and therapeutic effect through regulating the gut microbiota and their metabolic products, in order to provide ideas for the prevention and treatment of malignant tumor.