135例急性血吸虫病例IHA检测抗体滴度效价分析

目的分析急性血吸虫病确诊病例间接血凝试验(IHA)检测抗体滴度效价,为诊断与治疗急性血吸虫病提供依据。方法以2001年以来收治住院的135例急性血吸虫病确诊病例为观察对象。采集病人基本情况,询问疫水接触情况等,并进行IHA抗体滴度效价检测,比较不同年龄、潜伏期与住院天数之间的相关性。结果 135例病例中IHA检测抗体滴度均1∶320,其中滴度1∶640、1∶1 280、1∶2 560、1∶5 120、1∶10 240分别占1.48%、28.15%、35.56%、20.00%、14.81%。急性感染病例的平均年龄47.70±14.58岁,平均潜伏期38.03±4.59 d,平均住院时间15.08±3.79 d。抗体滴度效价与年龄分布无相关性(r=0.109,P0.05),差异无统计学意义(F=0.64,P0.05),但与潜伏期呈负相关(r=-0.558,P0.01)、住院时间呈正相关(r=0.791,P0.01),各组差异均有统计学意义(F=17.07、64.53,P均0.01)。结论 IHA检测急性血吸虫病例抗体滴度效价均在1∶640及以上,抗体滴度效价与年龄大小无相关性,抗体滴度效价高者,血吸虫病潜伏期短、住院时间长。

Analysis of antibody titer value of IHA in 135 acute schistosomiasis patients

Objective To analyze the antibody titer value of indirect haemagglutination test （IHA） in 135 confirmed acute schistosomiasis patients， so as to provide the evidence for improving the diagnosis and treatment of acute schistosomiasis. Methods A total of 135 acute schistosomiasis inpatients were selected from 2001 to 2006. They all received the IHA antibody titer detection， and the correlation among the age， incubation period， and hospitalization days was calculated. Results The antibody titers of IHA were higher than 1∶320 in all the cases. The percentages of 1∶640， 1∶1 280， 1∶2 560， 1∶5 120 and 1∶10 240 were 1.48%， 28.15%， 35.56%， 20.00%， and 14.81% respectively. The mean age was （47.70 ± 14.58） years， average incubation period was （38.03 ± 4.59） days and mean hospital stay time was （15.08 ± 3.79） days. The antibody titer value had no correlation with the age distribution （r = 0.109， P > 0.05）. There was a negatively correlation between the antibody titer value and incubation period， （r = -0.558， P <0.01）， there was a positive correlation between the antibody titer value and hospitalization time （r = 0.791， P < 0.01）， and there were significant differences among different groups （F = 17.07， 64.53， both P < 0.01）. Conclusions The antibody titer of acute schistosomiasis cases detected by IHA is 1∶640 and above. There is no correlation between the antibody titer value and age， but the antibody titer value is higher， the incubation period is shorter and hospitalization time is longer.