血清学检测对妊娠合并肝内胆汁淤积症病人病情严重程度的评估价值

探讨血中总胆汁酸(TBA),血清抑制素A(INH-A)及可溶性细胞间黏附因子-1(sICAM-1)水平对妊娠合并肝内胆汁淤积症(ICP)病人病情严重程度的评估价值,选取本院100例ICP患者作为观察组,50例健康体检者作为对照组。结果显示,与对照组比较,观察组患者TBA,INH-A,sICAM-1显著增高,其中,重度组显著高于轻度组；联合TBA、INH-A、sICAM-1检测对诊断ICP病情程度进行诊断的敏感度、特异度及AUC均高于各指标单独诊断(P<0.05)。结果提示,TBA、INH-A、sICAM-1联合检测可作为评估ICP患者病情严重程度的重要指标。

Value of serum test in evaluating the severity in patients with intrahepatic cholestasis of pregnancy

To evaluate the value of total bile acid (TBA), serum statin A(INH-A) and soluble intercellular adhesion factor-1 (sICAM-1) in diagnosis of intrahepatic cholestasis of pregnancy(ICP), 100 cases of ICP patients in our hospital were as observation group, and 50 healthy subjects were selected as the control group. The results showed, compared to normal control group, the blood levels of TBA, INH-A and sICAM-1 in the observation group were significantly higher, and the sensitivity, specificity and AUC in diagnosis of ICP degree with the together testing of the TBA, INH-A and sICAM-1 were higher than those of the testing each alone (P<0.05), suggesting together testing of the TBA, INH-A and sICAM-1 can be used as an important indicator to assess the severity of ICP patients'' conditions.