558例维吾尔族肺癌患者的临床病理特征及预后分析

目的 分析新疆本地维吾尔族肺癌患者的临床病理特征，了解该民族肺癌的分布特点及差异。方法 收集新疆医科大学附属肿瘤医院2005年1月1日至2014年12月31日就诊的558例维吾尔族肺癌患者，对患者的临床分期、病理类型、驱动基因等临床资料进行对比分析及随访。结果 男女比例1.37:1，女性和城市维吾尔族肿瘤患者中腺癌最多，而男性、有吸烟史和乡镇患者中鳞癌和小细胞肺癌居多；小细胞肺癌患者3年生存率最低，腺癌最高；21.8%（65/298）患者存在EGFR基因突变，多见于不吸烟、腺癌、女性患者；6.9%（11/159）患者存在EML4-AL基因融合，多表达于腺癌、不吸烟或既往有吸烟史，同时无EGFR突变患者；Ⅳ期EGFR基因突变患者与EGFR野生型患者总生存期（OS）差异无统计学意义（P=0.597）。Ⅳ期EML4-ALK基因融合患者与EML4-ALK基因未融合患者总生存期差异无统计学意义（P=0.941）。结论 维吾尔族肺癌患者在临床特征、病理类型、流行病学分布及驱动基因方面有其特点。病理类型和分期是影响维吾尔族NSCLC患者预后的独立因素。

Clinicopathological Characteristics and Prognosis of Uygur Lung Cancer Patients: A Report of 558 Cases

Objective To analyze the differences of the morbidity, clinicopathologic features and prognosis of Uygur lung cancer patients in Xinjiang. Methods We collected the clinical data of 558 Uygur lung cancer patients treated in the Affiliated Cancer Hospital of Xinjiang Medical University from January 1st, 2005 to December 31st, 2014. Comparative analysis and follow-up visit were conducted on TNM stage, pathological type, driver gene, etc.. Results The male/female ratio was 1.37:1. Lung adenocarcinoma was dominating among the female and urban patients, while squamous carcinoma and small cell lung cancer mostly occurred in the male and rural patients and those with smoking history. Small cell lung cancer patients had the lowest 3-year survival rate, and lung adenocarcinoma patients had the highest 3-year survival rate; 21.8%(65/298) of these patients had EGFR gene mutation and mainly were nonsmoking, adenocarcinoma and female patients; 6.9% (11/159) had EML4-AL gene fusion, and mostly expressed in the adenocarcinoma patients, nonsmoking patients or the patients with smoking history but without EGFR gene mutation. The difference in overall survival (OS) between the patients with EGFR gene mutation in stage Ⅳ and the EGFR wild-type patients was not significant statistically (P=0.597). The difference in overall survival (OS) between the patients with EML4-ALK gene fusion in stage Ⅳ and the patients without EML4-ALK gene fusion was not significant statistically (P=0.941). Conclusion Uygur lung cancer patients have relevant characteristics in clinical features, pathological type, epidemiological distribution and driver gene. Pathological type and TNM stage are independent factors influencing the prognosis of Uygur NSCLC patients.