非视紫质G蛋白偶联受体激酶对肿瘤的调控作用

G蛋白偶联受体激酶(G protein-coupled receptor kinases, GRKs)通过特异性地磷酸化活化状态的G蛋白偶联受体(G protein-coupled receptors, GPCRs)终止GPCR信号转导、以及磷酸化非GPCR等参与广泛细胞生理和病理活动。近些年有关GRKs与肿瘤发生和演进的关系研究取得了长足进展,但详细的分子机制有待进一步揭示。本文讨论非视紫质GRKs对多种肿瘤细胞的不同调控作用,以期为深入开展该领域研究提供新思路。

Regulation Role of Non-Rhodopsin G Protein-coupled Receptor Kinases on Tumor

G protein-coupled receptor kinases (GRKs) are involved in a wide range of cellular physiology and pathological activities by specifically phosphorylating activated G-protein coupled receptors (GPCRs) to terminate GPCR signaling and phosphorylating non-GPCR substrates. Although significant progress has been made in the study of the relationship between GRKs and tumor pathogenesis in recent years, the detailed molecular mechanism needs to be further elucidated. This article discusses the diverse role of non-rhodopsin GRKs in the regulation of a variety of tumor cells, with the goal to provide new ideas for further research in this field.