3D打印技术辅助外固定架治疗下肢复杂性骨缺损

目的探讨利用3D打印技术辅助外固定架治疗下肢复杂性骨缺损的临床疗效。方法回顾性分析2017年1月至2018年12月收治的12例下肢复杂性骨缺损资料。其中,男7例,女5例,年龄12~48岁,平均32岁。12例资料分为3D组和传统组,各6例。采用Fugl-Meyer评价量表对患者情况进行疗效评价,所得数据用SPSS19.0软件进行统计学分析。结果所有患者均获随访,时间6~12个月(平均时间8个月)。3D组和传统组在患者的年龄、性别、搬移时间骨痂矿化时间及HSS膝关节功能评分方面上差异无统计学意义(P>0.05),而两组手术时间、术中出血量、透视次数对比,差异有统计学意义(P<0.05)。根据Fugl-Meyer评价量表对患者情况进行疗效评价,3D组评分高于传统组(P<0.05)。结论应用3D打印技术可以提前制订术前计划并进行手术预演,使手术更精准、更微创。术后患者依从性好、满意度高,能获得更好的术后效果。

Application of 3D printing assisted external fixator in the treatment of complex bone defects of lower limbs

Objective To explore the clinical effect of 3D printing assisted external fixator in the treatment of complex bone defects of lower limbs. Methods Data of 12 cases of lower extremity complex bone defects admitted from January 2017 to December 2018 were retrospectively analyzed. There were 7 males and 5 females, aged from 12 to 48 years, with an average age of 32 years. The 12 cases were divided into 3D group and traditional group, 6 cases each. The Fugl-Meyer evaluation scale was used to evaluate the efficacy of the patients, and the obtained data were statistically analyzed by SPSS 19.0 software. Results All patients were followed up for 6 to 12 months (mean 8 months). There was no significant difference between the 3D group and the traditional group in terms of age, gender, moving time, callus mineralization time and HSS knee function score (P>0.05), while the difference in operation time, intraoperative blood loss and fluoroscopy frequency between the two groups was statistically significant (P<0.05). According to the Fugl-Meyer evaluation scale, the efficacy of patients in the 3D group was evaluated higher than that in the traditional group (P<0.05). Conclusion The application of 3D printing technology can make the preoperative plan in advance and perform the operation preview, making the operation more accurate and minimally invasive. Patients with good postoperative compliance and high satisfaction can obtain better postoperative results. reinforcer and study the oxidative stress of PEEK/SPEEK/HA biomaterial on bone environment cells. Methods Osteoblasts MG-63 cells and fibroblasts 3T3 cells were selected as the research objects to compare the effects of biomaterials on ROS and MDA levels of the two kinds of cells and to observe the growth morphology of the two kinds of cells on PEEK/SPEEK/30% HA materials. Results The oxidative stress level of MG-63 cells and 3T3 cells increased when cultured on PEEK and SPEEK materials, but PEEK/HA was lower than PEEK and SPEEK materials. Compared with PEEK materials, SPEEK materials can reduce the oxidative stress level of cells, PEEK/SPEEK/HA biomaterials made the oxidative stress level of MG-63 cells and 3T3 cells lower than PEEK/HA biomaterials, when the HA content reached 30%, the oxidative stress level of MG-63 cells was close to normal and the growth of the two cells on the surface of the biomaterials was unrestricted. Conclusion The introduction of HA and SPEEK could reduce the oxidative effect of cells.