| NPPV治疗AECOPD合并重度呼吸性酸中毒失败相关因素分析 |
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| 引用本文： | 范小玉,李秀. NPPV治疗AECOPD合并重度呼吸性酸中毒失败相关因素分析[J]. 临床肺科杂志, 2019, 24(5): 822-826 |
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| 作者姓名： | 范小玉 李秀 |
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| 作者单位： | 安徽医科大学第三附属医院, 安徽 合肥,230001;安徽医科大学第三附属医院, 安徽 合肥,230001 |
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| 摘 要： | 目的研究无创正压通气(NPPV)治疗慢性阻塞性肺疾病急性加重(AECOPD)合并重度呼吸酸性中毒(PH<7.25)疗效相关因素,为临床合理应用NPPV提供依据。方法回顾性研究NPPV治疗AECOPD合并重度呼吸性酸中毒(PH<7.25)患者90例,按照转归分为失败组与成功组,比较两者临床指标,并应用logistic回归筛选出独立影响因素。结果①共收集90例病人,68例(75.6%)NPPV成功,22例(24.4%)NPPV失败。②NPPV治疗前格拉斯哥昏迷评分(GCS)、急性生理与慢性健康评分(APACH II评分),及NPPV治疗2-4h PaCO_2值、GCS,成功组与失败组差别有统计学意义(P<0.05);③多因素Logistic回归分析结果显示:NPPV治疗2-4h后GCS评分(OR=0.451,95%CI 0.221-0.923)和NPPV治疗2-4h后PaCO_2值(OR=1.054,95%CI=1.012-1.098)。结论 NPPV治疗AECOPD合并重度呼吸性酸中毒失败的可能因素为NPPV治疗2-4h后低GCS评分和高PaCO_2值。
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| 关 键 词： | 慢性阻塞性肺疾病急性加重 无创正压通气 重度呼吸性酸中毒 呼吸衰竭 相关因素 |
Analysis of factors related to the failure of NPPV in the treatment of AECOPD complicated with severe respiratory acidosis |
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| FAN Xiao-yu,LI Xiu. Analysis of factors related to the failure of NPPV in the treatment of AECOPD complicated with severe respiratory acidosis[J]. Journal of Clinical Pulmonary Medicine, 2019, 24(5): 822-826 |
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| Authors: | FAN Xiao-yu LI Xiu |
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| Affiliation: | (Department of Pulmonary Medicine, the Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001, China) |
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| Abstract: | FAN Xiao-yu;LI Xiu(Department of Pulmonary Medicine, the Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001, China) |
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| Keywords: | acute exacerbation of chronic obstructive pulmonary disease noninvasive positive pressure ventilation respiratory failure severe respiratory acidosis related factors |
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