抗肿瘤药物相关性心血管疾病的发生机制研究进展

在肿瘤患者的死亡原因中，恶性肿瘤本身导致的死亡为首位原因，其次为抗肿瘤治疗相关性心脏疾病。肿瘤和心血管疾病作为最主要的慢性非传染性疾病，抗肿瘤药物治疗可能导致多种心血管事件，并日益受到关注。抗肿瘤药物包括化疗药物、分子靶向药物和免疫检查点抑制剂，多数可引起不同程度的心血管疾病，称为抗肿瘤药物治疗相关性心脏病。本文重点讨论各种抗肿瘤药物引发心血管疾病的发病机制，为肿瘤研究和临床实践提供参考。

Pathogenesis of Anti-cancer Drugs-induced Cardiovascular Diseases: The State-of-the-art

Among the death cause of cancer, the malignancies themselves were the top cause and the anticancer therapy-associated heart cardiovascular disease was the second one. Both cancer and cardiovascular disease are the common chronic non-communicable diseases. And various anti-cancer drugs would inevitably induce some cardiovascular events. These anti-cancer drugs include the traditional cytotoxic agents, molecularly targeted drugs and immunological checkpoint inhibitors. In this review, the possible pathogenesis of anti-cancer drug-induced cardiovascular diseases will be discussed, which will be useful for the cancer research and oncological clinical practice.