生物碱类化合物抗结核病的研究进展

结核病是全球发病率和死亡率较高的疾病之一,面对越来越严峻的挑战,寻找新途径、新思路研发抗结核病新药是战胜结核病的关键。生物碱类化合物在天然产物中分布广泛,具有生物来源多样性、化学结构多样性和生物活性多样性等特点,大多生物碱类化合物具有抗结核病的活性。综述近年来生物碱类化合物抗结核病作用及其相关机制的研究进展,以期总结不同类型生物碱抗结核病的特点,为该类化合物抗结核病的进一步深入研究与开发利用提供参考。

Research advances on alkaloids against tuberculosis

Tuberculosis is one of the diseases with high incidence and mortality in the world. In the face of the increasing severe challenges of tuberculosis, there is a key to fight against tuberculosis by finding new ways and new ideas to develop new anti-tuberculosis drugs. Alkaloid compounds are widely distributed in natural medicines, which have the characteristics of biodiversity, chemical structure diversity and biological activity diversity, and most alkaloids have anti-tuberculosis activity. This article reviews the research progress of the effects of alkaloids on tuberculosis and the mechanism of anti-tuberculosis in recent years, which may summarize the characteristics of different types of alkaloids against tuberculosis and provide reference for further research, development and utilization of these compounds against tuberculosis.