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| 去氢骆驼蓬碱PLGA纳米粒包封率测定方法的研究 | |
| 引用本文： | 张美玲,刘恒戈,黄川生,陈卫军,王新春. 去氢骆驼蓬碱PLGA纳米粒包封率测定方法的研究[J]. 农垦医学, 2010, 32(5): 388-390 |
| 作者姓名： | 张美玲 刘恒戈 黄川生 陈卫军 王新春 |
| 作者单位： | 1. 石河子大学药学院,新疆石河子,832002 2. 新疆医科大学附属肿瘤医院,乌鲁木齐,830011 3. 石河子大学医学院第一附属医院,新疆石河子,832008 4. 石河子大学药学院,新疆石河子,832002;石河子大学医学院第一附属医院,新疆石河子,832008 |
| 基金项目： | 石河子大学医学院第一附属医院科研起动资金专项 |
| 摘 要： | 目的：建立去氢骆驼蓬碱聚乳酸乙醇酸共聚物纳米粒（Hm-PLGA-NP）包封率测定方法。方法：采用透析法分离纳米粒样品中的游离药物及Hm-PLGA-NP,紫外分光光度法测定包封率。结果：透析法能有效分离Hm-PLGA-NP与游离去氢骆驼蓬碱,药物平均加样回收率是99.04%,透析法平衡时间为8h,Hm-PLGA-NP药物的平均包封率为80.3%。结论：透析法用于测定Hm-PLGA-NP药物包封率,具有准确、简单的优势。 |
| 关 键 词： | 去氢骆驼蓬碱 聚乳酸乙醇酸共聚物纳米粒 包封率 透析法 |
Determination of entrapment efficiency of harmine PLGA nanoparticles |
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| ZHANG Mei-ling,LIU Heng-ge,HUANG Chuan-sheng,CHEN Wei-jun,WANG Xin-chun. Determination of entrapment efficiency of harmine PLGA nanoparticles[J]. Agricultural Reclamation Medicine, 2010, 32(5): 388-390 | |
| Authors: | ZHANG Mei-ling LIU Heng-ge HUANG Chuan-sheng CHEN Wei-jun WANG Xin-chun |
| Affiliation: | 1.Pharmacy of college,Shihezi University,Xinjiang Shihezi,832002;2.Affiliated tumor hospital; Xinjiang Medical University;Urumqi,830011;3.The first affiliated hospital of medical college, Shihezi University School of Medicine,Xinjiang Shihezi,832008) |
| Abstract: | Objective：To determine the entrapment efficiency of Harmine PLGA Nanoparticles（Hm-PLGA-NP）. Methods：Dialysis method was used to determine the entrapment efficiency of Hm-PLGA-NP,and the entrapment efficiency was determined by ultraviolet spectrophotometry.Results：Free Hm could be effectively separated from Hm-PLGA-NP by Dialysis method.The equilibrium time was 8h and the sample average recovery was 80.3%.The average entrapment efficiency of Hm-PLGA-NP was 99.04%.Conclusion：The method used in this study is simple,applicable and accurate for determination of the entrapment efficiency of Hm-PLGA-NP. |
| Keywords: | harmine PLGA nanoparticles entrapment efficiency dialysis |
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