| 去氢骆驼蓬碱固体脂质纳米粒制备工艺的研究 |
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| 引用本文： | 黄川生,刘恒戈,王新春,陈卫军.去氢骆驼蓬碱固体脂质纳米粒制备工艺的研究[J].农垦医学,2010,32(6):487-489. |
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| 作者姓名： | 黄川生 刘恒戈 王新春 陈卫军 |
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| 作者单位： | [1]石河子大学药学院,新疆石河子832002 [2]新疆医科大学附属肿瘤医院,乌鲁木齐830011 [3]石河子大学医学院第一附属医院,新疆石洞子832008 |
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| 基金项目： | 石河子大学医学院第一附属医院科研起动资金专项 |
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| 摘 要： | 目的：优化去氢骆驼蓬碱固体脂质纳米粒（HM-SLN）的制备工艺。方法：以包封率、载药量及稳定性为评价指标,采用正交试验法优选处方和制备工艺,并对优选条件下制得的HM-SLN进行质量评价。结果：以优化处方制备的去氢骆驼蓬碱固体脂质纳米粒平均粒径为121nm,包封率为（88.11±0.585）%,载药量为（2.03±0.005）%。结论：本优化工艺制备HM-SLN包封率较高,稳定性好,方法可靠。
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| 关 键 词： | 去氢骆驼蓬碱 固体脂质纳米粒 正交设计 二次高剪切超声 |
Studies on the Preparation of Harmine Solid Lipid Nanoparticles |
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| HUANG Chuan-sheng,LIU Heng-ge,WANG Xin-chun,CHEN Wei-jun.Studies on the Preparation of Harmine Solid Lipid Nanoparticles[J].Agricultural Reclamation Medicine,2010,32(6):487-489. |
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| Authors: | HUANG Chuan-sheng LIU Heng-ge WANG Xin-chun CHEN Wei-jun |
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| Institution: | 1.Pharmacy of college,Shihezi University,Xinjiang Shihezi,832002;2.affiliated tumor hospital,Xinjiang Medical University,Urumqi,830011;3.the first affiliated hospital,Shihezi University School of Medicine,Xinjiang Shihezi,832008) |
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| Abstract: | Objective： To prepare the Harmine solid lipid nanoparticles（HM-SLN）.Methods：The preparation of HM-SLN was optimized by orthogonal design with the encapsulate efficiency（EE%）,drug loading（DL%） and stability as evaluation parameters.Then the quality of the obtained HM-SLN was determinated.Results：The obtained HM-SLN had even with a mean diameter of 121 nm,the encapsulate efficiency ratio and the drug loading of the prepared HM-SLN was（88.11±0.585）% and（2.03±0.005）%.Conclusion：The entrapment ratio of HM-SLN is high and the stability is good for HM-SLN prepared by twice high shear ultrasound method,and the method is reliable. |
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| Keywords: | harmine solid lipid nanoparticles orthogonal design twice high shear ultrasound method |
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