AFP、CEA和CA199联合检测在原发性肝癌诊断中的应用

目的：探讨多种血清肿瘤标志物联合检测对原发性肝癌的诊断价值。方法：采集110例原发性肝癌和152例良性肝病（肝硬化和慢性肝炎）患者血液,用化学发光法测定AFP、CEA和CA199水平。结果：原发性肝癌患者血清中AFP、CEA和CA199水平分别为（60.6±80.5）μg/L、（22.2±13.9）μg/L、（47.2±28.3）U/L,明显高于良性肝病患者血清水平;原发性肝癌患者中AFP、CEA和CA199阳性率分别为74.6%、49.1%和45.5%,显著高于良性肝病患者;三者联合检测将原发性肝癌检测敏感率提升至92.7%。结论：联合检测可提高原发性肝癌诊断的敏感率,在原发性肝癌的筛查中有一定的应用价值。

Diagnostic value of combined detection of AFP, CEA and CA199 in primary fiver cancers

Objective: To study the clinical value of combined detection of the serum levels of AFP,CEA and CA199 in primary liver cancers.Methods: Collecting the serum samples from 110 primary hepatic cancer patients and 152 benign liver disease patients(hepatic cirrhosis and chronic hepatitis),the serum levels of AFP,CEA and CA199 were measured by chemiluminescence.Results: The levels of AFP,CEA and CA199 were(60.6 ± 80.5) μg/L,(22.2 ±13.9) μg/L and(47.2 ±28.3) U/L in primary liver cancer patients respectively,it was significantly higher than that in benign liver disease patients.The serum positive ratio of AFP,CEA and CA199 in primary liver cancer patients were 74.6%,49.1% and 45.6%,respectively,it was significantly higher than that in benign liver disease patients too.The sensitivity of combined detection of three kinds of tumor markers was 92.7%.Conclusion: The combined detection of AFP,CEA and CA199 can arise the diagnosis sensitivity of primary hepat-ic cancer,it has some value in screening primary hepatic cancers.