| P53、C-erbB-2在乳腺癌中的表达及其预后价值 |
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| 引用本文： | 车艺,厉红元.P53、C-erbB-2在乳腺癌中的表达及其预后价值[J].重庆医学,2003,32(1):57-59. |
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| 作者姓名： | 车艺 厉红元 |
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| 作者单位： | 1. 重庆职工医学院病理生理学教研室,400050
2. 重庆医科大学附属第一医院普外科,400016 |
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| 摘 要： | 目的：探讨p53、C－erbB-2在人乳腺癌组织中的表达及预后评价中的作用。方法：免疫组化检测59例人乳腺癌石蜡切片p53、C－erbB-2的表达，并与肿瘤大小，淋巴结转移和肿瘤复发率对比分析。结果：p53阳性表达与腋淋巴结转移，肿瘤大小（P＜0．05）和肿瘤复发呈正相关（P＜0．01）；C－erbB-2阳性表达与腋淋巴结转移（P＜0．01）和肿瘤复发呈正相关（P＜0．05）；两者同时阳性表达亦与肿瘤复发呈显著正相关（P＜0．01＝，结论：p53、C－erbB-2表达与人乳腺癌预后有一定相关性，两者同时阳性表达可能提示预后更差。
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| 关 键 词： | P53基因 C－erbB－2基因 乳腺癌 预后 基因表达 免疫组织化学 |
| 文章编号： | 1671-8348(2003)01-0057-03 |
The Expression of p53 and C-erbB-2 and its role in prognosis of breast cancer |
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| CHE Yi ,LI Hong yuan.The Expression of p53 and C-erbB-2 and its role in prognosis of breast cancer[J].Chongqing Medical Journal,2003,32(1):57-59. |
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| Authors: | CHE Yi LI Hong yuan |
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| Institution: | CHE Yi 1,LI Hong yuan 2 |
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| Abstract: | Objective To study the expression of p53 and C erbB 2 and its prognostic value in breast cancer. Methods To assess p53 and C erbB 2 through immunohistochemical method in 59 breast cancer paraffin section and to makecontrast analysis with tumor size, lymphatic metastasis and recurrence rate.Results p53 expression was significantly correlated with axillary node status, tumor size( P <0.05) and recurrence rate( P <0.01). C erbB 2 expression was significantly correlated with axillary node status( P <0.01) and recurrence rate( P <0.05). Coexpression of p53 and C erbB 2 was also significantly correlated with recurrence rate ( P <0.01). Conclusions There are relationships between p53 expression or C erbB 2 expression and prognosis in breast cancer. The patient who had coexpression of p53 and C erbB 2 may have a worse result. |
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| Keywords: | breast cancer p53 and CerbB 2 gene expression prognostic |
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