The endothelium-derived relaxing factormediated acetylcholine response of the arterial perfusion pressure after cold storage of the isolated rabbit kidney |
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Authors: | Ayhan Kuzu Îskender Alaçayir Cüneyt Köksoy Özlem Yazar Ercüment Kuterdem |
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Affiliation: | (1) Department of Surgery, University of Ankara, Mertler sokak 52/1, Be tepe, TR-06510 Ankara, Turkey;(2) Department of Surgery and Pharmacology, University of Ankara, Sihhiye, Ankara, Turkey |
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Abstract: | The vasodilatation induced by acetylcholine (ACh) in a rabbit isolated perfused kidney was abolished when the tissue was exposed to cold ischemia for 72 h in Euro-Collins (EC) solution. This vasodilatation is due to the release of endothelium-derived relaxing factor (EDRF) from renal vasculature as evidenced by the attenuation following methylene blue pretreatment. When kidneys were preserved in EC solution containing UK 38 485, a thromboxane synthase inhibitor, or nicardipine, a calcium channel blocker, ACh-induced vasodilatation persisted after 72 h of cold ischemia. These results were taken as evidence of tissue protective activity of UK 38 485 and nicardipine and have promising implications for cadaveric kidney transplantation.This paper was presented at the 35th World Congress of the International Society of Surgery in Hong Kong in August 1993 |
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Keywords: | Kidney preservation, endothelium-derived relaxing factor Endothelium-derived relaxing factor, kidney preservation Preservation, kidney, endothelium-derived relaxing factor |
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