睡眠剥夺条件下服用咖啡因对工作绩效的影响

目的　探讨睡眠剥夺条件下服用咖啡因对工作绩效的影响。　方法　８ 名受试者用药前后自身对照，每名受试者重复５ 次实验。每次实验时在从６：００ 至次日９：００ 的２７ ｈ 的睡眠剥夺过程中于凌晨１：００ 分别服用安慰剂（食用淀粉）或咖啡因（ ２００ ｍ ｇ 和３００ ｍ ｇ）或苯丙胺（５ ｍ ｇ 和 １０ｍ ｇ），采用随机双盲给药。并在服药前１ ｈ 及服药后１ ｈ、３ ｈ、５ ｈ、７ ｈ 各完成一组认知任务工作绩效的测试。　结果　与安慰剂组比较，咖啡因可以显著降低单、双任务反应时、双任务跟踪误差（Ｐ＜０．０５）；服用咖啡因后主观任务难度降低（Ｐ＜ ０．０５） 。咖啡因 ２００ ｍ ｇ、３００ ｍ ｇ 的作用效果与苯丙胺５ ｍ ｇ、１０ ｍ ｇ 作用基本相当。咖啡因的这些作用在服药后１ ｈ 即可出现，持续至服药后７ ｈ。２００ ｍ ｇ 与３００ ｍ ｇ 咖啡因组间无显著差异（Ｐ＜ ０．０５）。　结论　咖啡因２００ ｍ ｇ 和咖啡因３００ ｍ ｇ 对于睡眠不足和睡眠剥夺引起的工作绩效的变化具有明显的改善作用

Effects of caffeine on perform ance during sleep deprivation

s Objective To investigate the effects ofcaffeine on perform ance during sleep de- privation. Methods Eighthealthy nonsm oking m ale college students served as subjects. They un- derw ent 5 tests in 5 days (once a w eek). During the test, they underw ent27 h sustained aw akeness (from 6:00 to 9:00 next m orning).Tw o capsules of5 differentcontents (am ylum , 200 m g caffeine, 300 m g caffeine,5 m g am phetam ine and 10 m g am phetam ine) w ere given in double blind w ay at 1:00. Tests on cognitive task perform ance and subjective rating on degree of task difficulty w ere done 1 h before taking drug and 1 h, 3 h, 5 h, 7 h after taking drug. Results Com pared w ith placebo, caffeine can shorten the reaction tim e ofsingle task and dualtask (P< 0.05), and decrease the tracking error ofdualtask significantly (P< 0.05). The subjective rating on degree oftask diffi- culty w as low ered significantly (P< 0.05).Caffeine began to exertaction 1 h after taking it. There w as no significantdifference betw een effects oftw o doses ofcaffeine. Conclusions Caffeine atdose of200 m g or 300 m g can prom ote cognitive task perform ance during sleep deprivation.