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| 黄芩苷元对大鼠心肌缺血再灌注损伤的保护作用 | |
| 引用本文： | 黄贤华,贺方兴,郑建锋,刘贤伟,黄常亮,杨芳炬.黄芩苷元对大鼠心肌缺血再灌注损伤的保护作用[J].中药药理与临床,2008,24(5). |
| 作者姓名： | 黄贤华 贺方兴 郑建锋 刘贤伟 黄常亮 杨芳炬 |
| 作者单位： | 1. 赣南医学院,药理教研室,赣州,341000 2. 赣南医学院,病理教研室,赣州,341000 3. 四川大学华西医学中心药理教研室,成都,610041 |
| 基金项目： | 国家重点基础研究发展规划(973计划) |
| 摘 要： | 目的:观察黄芩苷元(Baicalein,Bai)对大鼠心肌缺血再灌注损伤的保护作用及其机制。方法:结扎大鼠左冠状动脉前降支以制备心肌缺血再灌注损伤模型,比色法检测大鼠血清中超氧化物歧化酶(SOD)、丙二醛(MDA)、髓过氧化物酶(MPO)、乳酸脱氢酶(LDH)水平和心肌中LDH、肌酸激酶(CK)含量;放射免疫法测血浆中内皮素(ET)和心钠素(ANP)的含量。结果:与模型组比,Bai能降低血清中LDH、MDA、MPO含量,提高血清中SOD活性;降低血浆中ET含量,提高血浆中ANP水平;增加心肌中LDH、CK含量。结论:Bai对心肌缺血再灌注损伤有保护作用,作用机制可能与其抗氧化、减少心肌酶的漏出等作用有关。 |
| 关 键 词： | 黄芩苷元 心肌缺血 再灌注损伤 |
Protection effect of baicalein on myocardial ischemia-reperfusion injury in rats |
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| Huang Xianhua,He Fangxing,Zheng Jianfeng,et al.Protection effect of baicalein on myocardial ischemia-reperfusion injury in rats[J].Pharmacology and Clinics of Chinese Materia Medica,2008,24(5). | |
| Authors: | Huang Xianhua He Fangxing Zheng Jianfeng |
| Institution: | Huang Xianhua1,He Fangxing2,Zheng Jianfeng1,et al(1Department of Pharmacology,2Department of Pathology,Gannan Medical College Ganzhou 341000) |
| Abstract: | Objective: To investigate protection effect of baicalein on myocardial ischemia-reperfusion injury in rats.Methods: The myocardial ischemia-reperfusion injury model in rats were established by ligating left anterior descending coronary artery.Content of lactate dehydrogenase(LDH),superoxide dismutase(SOD),malondialdehyde(MDA),myeloperoxi-dase(MPO) in serum and LDH,creatine kinase(CK) in myocardium were measured by chromatometry;Content of endothelin(ET) and atrial natriuretic peptide(ANP) were measured in p... |
| Keywords: | baicalein myocardial ischemia reperfusion injury |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |