| 短期能量限制对成年雌性大鼠生殖寿命的影响 |
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| 引用本文： | 陈晓纯,罗丽莉,许锦阶,傅玉才,栗丽,林旋豪. 短期能量限制对成年雌性大鼠生殖寿命的影响[J]. 汕头大学医学院学报, 2011, 24(3): 141-144 |
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| 作者姓名： | 陈晓纯 罗丽莉 许锦阶 傅玉才 栗丽 林旋豪 |
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| 作者单位： | 1. 汕头大学医学院第一附属医院妇产科
2. 汕头大学医学院细胞衰老实验室,广东汕头,515041 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的：探讨短期能量限制对雌性大鼠生殖寿命的影响。方法：21只8周龄雌性sD大鼠随机分为对照组和能量限制组，并监测大鼠体质量及动情周期变化，8周后取大鼠卵巢，其切片由苏木精．伊红染色，观察存活卵泡数和不同发育阶段的卵泡比例。结果：对照组体质量持续上升，能量限制组较平缓。能量限制组健康卵泡（135．3．4±11．7）比对照组（90．7±7．1）多（P〈0．05），原始卵泡数（57．7±7．7）与对照组（19．4±4．0）比显著增多（P〈0．001），原始卵泡比例（41．9±2．9）比对照组（20．5±3．5）要多（P〈0．01），而发育和成熟卵泡比例与对照组比则降低。结论：短期能量限制可能通过抑制卵泡发育启动、减少每个周期成熟卵泡的个数来降低卵泡消耗，有益于生殖寿命延长。
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| 关 键 词： | 能量限制 生殖寿命 卵巢 卵泡发育 |
Effects of Short-term Calorie Restriction on the Ovarian Lifespan in Female Rats |
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| CHEN Xiao-chun,LUO Li-li,XU Jin-jie,FU Yu-cai,LI Li,LIN Xuan-hao. Effects of Short-term Calorie Restriction on the Ovarian Lifespan in Female Rats[J]. Journal of Shantou University Medical College, 2011, 24(3): 141-144 |
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| Authors: | CHEN Xiao-chun LUO Li-li XU Jin-jie FU Yu-cai LI Li LIN Xuan-hao |
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| Affiliation: | CHEN Xiao-chun1,LUO Li-li1,XU Jin-jie2,FU Yu-cai2,LI Li1,LIN Xuan-hao2(1 Department of Gynaecology and Obstetrics,The First Affiliated Hospital,Shantou University Medical College,Shantou 515041,China,2 Laboratory of Cell Senescence,China) |
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| Abstract: | Objective:To investigate the effects of short-term calorie restriction on the ovarian reproductive extension in female rats.Methods:Female Sprague-Dawley rats(n = 21)were randomly divided into normal control and calorie restriction groups.The body mass was monitored every week,and the estrous cycle patterns were determined by vaginal smears everyday.Ovaries were collected from the rats after 8 weeks.Ovarian tissue sections were prepared and the hematoxylin and eosin staining was performed to examine the rat... |
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| Keywords: | calorie restriction reproductive lifespan ovarian follicular development |
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