| 碘化Ⅳ-正丁基氟哌啶醇对大鼠心肌细胞肌浆网钙泵的保护作用 |
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| 引用本文： | 王春燕,石刚刚. 碘化Ⅳ-正丁基氟哌啶醇对大鼠心肌细胞肌浆网钙泵的保护作用[J]. 汕头大学医学院学报, 2011, 24(3): 135-137,126 |
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| 作者姓名： | 王春燕 石刚刚 |
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| 作者单位： | 汕头大学医学院药理学教研室,广东汕头,515041 |
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| 基金项目： | 国家自然科学基金-广东省联合重点项目，教育部博士点基金资助项目 |
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| 摘 要： | 目的：研究碘化-Ⅳ-正丁基氟哌啶醇（F2）对大鼠心肌细胞肌浆网钙泵（SERCA）的保护作用。方法：通过结扎成年SD大鼠冠状动脉左前降支造成急性心肌缺血再灌注（L／R）模型，舌下静脉给予不同剂l（0．3、0．5、1．0、2．0和4．0mg/kg）F2，测定SERCA的活性和蛋白表达变化。结果：I／R组SERCA活性为对照组的57．7％、不同剂量F2组分别为67．1％、72．8％、77．4％、84．1％和86．7％。结论：15能量效-依赖地减轻I／R导致的SERCA活性降低。
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| 关 键 词： | 碘化Ⅳ．正丁基氟哌啶醇 肌浆网钙泵 缺血再灌注 |
The Protectivie Effects of N-n-butyl Haloperidol Iodide on Sarcoplasmic Reticulum Ca2 + -ATPase of Cardiac Myocytes in Rats |
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| WANG Chun-yan,SHI Gang-gang. The Protectivie Effects of N-n-butyl Haloperidol Iodide on Sarcoplasmic Reticulum Ca2 + -ATPase of Cardiac Myocytes in Rats[J]. Journal of Shantou University Medical College, 2011, 24(3): 135-137,126 |
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| Authors: | WANG Chun-yan SHI Gang-gang |
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| Affiliation: | WANG Chun-yan,SHI Gang-gang(Department of Pharmacology,Shantou University Medical College,Shantou 515041,China) |
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| Abstract: | Objective： To investigate the protective effects of N-n-butyl haloperidol iodide on sarcoplasmic reticulum Ca^2＋-ATPase（SERCA）of cardiac myoeytes in rats. Methods： The experimental models of rots were established by occluding left anterior descending coronary artery, and intravenous various doses of 172 before I/R. The activity of SERCA was observed by tested kits and the quantity of SERCA was tested. Results： The activity of SERCA decreased after IfR. SERCA was reduced to 57.7 % （ P 〈 0.05）. Intravenous 172 at 0.3 、0.5, 1. 0、2.0 and 4.0 mg/kg before isehemia reduced SERCA to67.1%、72.8%, 77.4%、84.1%、86.7% respectively. The quantity of SERCA had no changes. Conclusion： Intravenous F2 in rats could ameliorate the decreased activity of SERCA dose-deoendently. |
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| Keywords: | N-n-butyl haloperidol iodide sarcoplasmic reticulum Ca2 -ATPase ischemia-reperfusion |
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