| 祛风通络方对系膜增生性肾小球肾炎大鼠蛋白尿及血清IL-6与IL-8的影响 |
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| 引用本文： | 孙万森,王娟,王竹,马巧亚,张晓强,吴喜利.祛风通络方对系膜增生性肾小球肾炎大鼠蛋白尿及血清IL-6与IL-8的影响[J].中国中西医结合肾病杂志,2009,10(7):584-586,I0003. |
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| 作者姓名： | 孙万森 王娟 王竹 马巧亚 张晓强 吴喜利 |
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| 作者单位： | 1. 西安交通人学医学院第二附属医院中西医结合科,西安,710004
2. 西安交通大学医学院第二附属医院中国皮肤性病学杂志编辑部,西安,710004 |
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| 基金项目： | 陕西省科技计划项目，陕西省中医管理局基金 |
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| 摘 要： | 目的：探讨祛风通络方对系膜增生性肾小球肾炎大鼠蛋白尿及血清白细胞介素-6（IL-6）、白细胞介素-8（IL-8）的影响。方法：采用免疫法制备系膜增生性肾小球肾炎大鼠模型,应用磺柳酸法测定大鼠24h尿蛋白定量,双抗体夹心ELISA法检测大鼠血清IL-6、IL-8,光镜下观察各组大鼠肾小球系膜区（GMC）及细胞外基质（ECM）积聚变化。结果：模型组与正常对照组比较24h尿蛋白定量及血清IL-6、IL-8明显升高（P〈0.01）;祛风通络方组24h尿蛋白定量及血清IL-6、IL-8均明显低于模型组（P〈0.01）;肾组织形态学观察显示祛风通络方组个别区域肾小球系膜细胞轻度增生,系膜区轻度增宽,管腔无挤压现象,较模型组明显改善。结论：祛风通络方组降低系膜增生性肾小球肾炎大鼠尿蛋白,降低血清IL-6、IL-8水平,减轻系膜细胞增生和细胞外基质增加,延缓或减轻肾组织损伤,保护肾功能。
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| 关 键 词： | 祛风通络方 系膜增生性肾小球肾炎 蛋白尿 白细胞介素-6 白细胞介素-8 |
Effects of qufengtongluo Recipe on Levels of Proteinuria and Serum IL-6 and IL-8 in Mesangial Proliferative Glomerulonephritis Rats |
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| SUN Wansen,WANG Juan,WANG Zhu,et al.Effects of qufengtongluo Recipe on Levels of Proteinuria and Serum IL-6 and IL-8 in Mesangial Proliferative Glomerulonephritis Rats[J].Chinese Journal of Integrated Traditional and Western Nephrology,2009,10(7):584-586,I0003. |
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| Authors: | SUN Wansen WANG Juan WANG Zhu |
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| Abstract: | Objective:To explore the effect of qufengtongluo recipe on the levels of proteinuria and serum IL-6 and IL-8 in mesangial proliferative glomerulonephritis rats.Methods:Model of mesangial proliferative glomerulonephritis was made with immunization.The level of 24 h urine protein was determined with the sulfosalicylic acid-sodium sulfate turbidimetry;Serum IL-6 and IL-8 were assayed with double antibody ELISA.Each group of the membrane cell(GMC) and the extracelluar matrix(ECM) were observed with light micros... |
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| Keywords: | Qufengtongluo recipe Mesangial proliferative glomerulonephritis Proteinuria IL-6 IL-8 |
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