迷走神经在电针提高急性心肌缺血早期室颤阈中的作用

目的 通过动物实验观察电针对急性心肌缺血所致的ＶＦＴ降低的影响，分析探讨迷走神经在电针提高ＶＦＴ中的作用机制。方法 用结扎兔冠脉建立急性心肌缺血动物模型，观察比较对照组、电针组、切断迷走神经组等室颤阈值、血浆ｃＡＭＰ、ｃＧＭＰ，并对其心率变异频谱特征进行分析。结果 实验显示电针能显示提高缺血心肌的ＶＦＴ（Ｐ〈０．０５，Ｐ〈０．０１）；切断迷走神经后，电针的这一作用消失（Ｐ〈０．０５，Ｐ〈０．０１）

The Role of Vagus Nerve in Raising Ventricular Fibrillation Threshold(VFT) of Early Acute Myocardial Ischemia by Electro acupuncture

Objective To observe the effect of electro acupuncture (EA) on the ventricular fibrillation threshold(VFT) of early acute myocardial ischemia experimental animal, and probe into action mechanism of vegetative nerve in raising VFT by EA. Methods We made the acute myocardial ischemia rabbit model by ligating coronary artery to observe VFT, the content of plasma cAMP and cGMP, and make power spectrum analysis of heart rate in control group, EA group and cutting off vagus nerve group. Results EA could remarkably raise VFT of early acute myocardial ischemia ( P < 0.05 , P <0.01), and the EA effect disappeared after cutting off vagus nerve ( P < 0.05 , P <0.01); EA could markedly reduce the content of cAMP and raise cGMP, adjust the ratio of cAMP/cGMP ( P < 0.05 , P <0.01); EA still stabilize total variation of heart rate, reduce ratio of LF/HF ( P < 0.05 , P < 0.01 ). Conclusion EA could raise the VFT of early acute myocardial ischemia, which is carried out by regulating tension and equilibrium of the sympathetic nerve and vagus nerve, and vagus nerve plays an important role in raising VFT of early acute myocardial ischemia by EA.