靶控麻醉对直肠癌根治术患者免疫功能变化的影响

目的：研究靶控麻醉对直肠癌根治术患者免疫功能变化的影响。方法选择2012年8月至2014年10月入组接受直肠癌根治术的患者68例，随机将其分为靶控麻醉组（34例）与对照组（34例），分别给予靶控麻醉或全身麻醉。结果麻醉成功后，靶控麻醉组患者的肿瘤坏死因子-α（tumor necrosis factorα，TNF-α）和血清白细胞介素-6（interleukin 6，IL-6）水平分别为（87000.00±180.00）μg/L和（125.00±24.00）ng/L，对照组TNF-α和IL-6分别为（73000.00±160.00）μg/L和（105.00±23.00）ng/L，差异均具有统计学意义（均P＜0.05）；靶控麻醉组患者的CD3+ T细胞、CD4+ T细胞和CD8+ T细胞降低程度分别为（52.98±5.74）%、（32.85±4.27）%和（22.52±4.20）%，对照组这三类细胞的降低程度分别为（58.14±5.65）%、（36.86±4.36）%和（24.68±4.69）%，差异均具有统计学意义（均P＜0.05）。结论与全身麻醉相比较，靶控麻醉能够明显抑制患者的免疫功能。

Effect of target-controlled anesthesia on the cellular immune function of patients receiving radical resection for rectal cancer

Objective To investigate the effect of target-controlled anesthesia on the cellular immune function of patients receiving radical resection for rectal cancer. Method Sixty-eight patients had radical resection for rectal can-cer from August 2012 to October 2014, and were divided into target-controlled anesthesia group (34 cases) and con-trol group (34 cases), and either target-controlled anesthesia or general anesthesia was applied in radical resection for both group, respectively. Result In the post-anesthesia observation, the target-controlled anesthesia group had TNF-α of (87000.00 ± 180.00) μg/L, IL-6 of (125.00 ± 24.00) ng/L, which were significantly higher than that of control group [TNF-α (73000.00 ± 160.00) μg/L, IL-6 (105.00 ± 23.00) ng/L (all P< 0.05)]. The decrease of CD3+ T cells, CD4+ T cells, and CD8+ T cells in target-controlled anesthesia group were (52.98 ± 5.74)%, (32.85 ± 4.27)%, (22.52 ± 4.20)%, respectively, and were significantly lower than those of the control group, which were (58.14 ± 5.65)%, (36.86±4.36)%, and (24.68±4.69)% in correspondence (all P< 0.05). Conclusion Compared with general anesthesia, target-controlled anesthesia significantly inhibits the cellular immune function in patients.