Enhanced chromosomal fragility in neuroblastoma: correlation with poor prognosis. |
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| Authors: | P Vernole B Tedeschi G Melino C Pianca B Nicoletti |
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| Affiliation: | Department of Public Health and Cell Biology, 2nd University of Rome, Italy. |
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| Abstract: | In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lymphocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin and a variety of personal and clinical characteristics were verified. Patients with a poor prognosis generally proved to be more susceptible to fragile site induction. |
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