产ESBLs细菌感染患者多重感染及其耐药性分析

目的：了解临床产ESBLs细菌感染患者并发多重感染流行分布情况以及多重感染细胞耐药性分析。方法：将ESBLs细胞感染患者的痰、血、尿等标本进行细菌培养并采用VITEK AMS系统对庆大霉素、亚胺培南等17种抗菌药物进行最低抑菌浓度（MIC）进行检测。结果：临床产ESBLs细菌感染患者，39.8%并发多重感染，主要分布于ICU病房，老年病科病房、儿科、呼吸科病房等，多重感染细胞主要是铜绿假单胞菌、金黄色葡萄球菌、肠球菌、阴沟肠杆菌等。结论：产ESBLs细菌感染患者相对于非ESBLs感染患者容易出现多重细菌感染，主要发生在年老体弱、免疫力低下、危重患者，参与多重感染的细菌多是临床难以控制、多重耐药菌。

MULTIPLE INFECTION IN PATIENTS WITH ESBL-PRODUCING BACTERIA

Objective:To investigate multiple infection in patients with ESBL-producing bacteria and antimicrobial resistance of co-infecting bacteria.Method:Clinical specimens from patients were cultrured,bacterial identification were performed by VITEK AMS system.MIC of different antimicrobial agents were analyzed by VITEK susceptibility cards.Results:Multiple infection occurred in 39.8% of patients with ESBL-producing bacteria.These patients are mainly from ICU,pediatric ward,respiratory ward.Co-infecting bacteria were mostly P.aeruginosa,S.aureus,Enterococcus.Conclusion:Patients with ESBL-producing bacteria are predisposed to multiple infection.Senile infantile and critical patients are susceptible population.Co-infecting bacteria are mainly multidrug resistant bacteria.