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| 氢溴酸加兰他敏贴剂体外释药性和经皮渗透性能研究 | |
| 引用本文： | 邓伟杰,张春凤,赵树进,罗佳波. 氢溴酸加兰他敏贴剂体外释药性和经皮渗透性能研究[J]. 广东药学院学报, 2009, 25(3): 237-241 |
| 作者姓名： | 邓伟杰 张春凤 赵树进 罗佳波 |
| 作者单位： | 1. 广州军区广州总医院,药剂科,广东,广州,510010 2. 中国药科大学,中药学院,江苏,南京,211198 3. 南方医科大学,中医药学院,广东,广州,510515 |
| 摘 要： | 目的研究氢溴酸加兰他敏贴剂的体外释放和经皮渗透性能。方法采用Franz扩散池装置和一阶导数光谱法考察氢溴酸加兰他敏贴剂的药物释放性能；采用Franz扩散池装置和高效液相色谱法考察氢溴酸加兰他敏贴剂经离体猪皮的渗透性能。结果氢溴酸加兰他敏贴剂（1．7mg·cm^-2）24h累积释放量均超过95％，释放曲线符合Higuchi方程，释放速率为（461．9±41．9）μg·cm^-2·h^-1/2（n=4）；贴剂24h累积渗透量为（20．904±3．050）μg·cm^-2，渗透曲线符合零级动力学方程，透皮速率为（1．270±0．229）μg·cm^-2·h^-1，透皮时滞为（6．4±0．7）h（n=6）。结论本研究制备的氢溴酸加兰他敏贴剂具有良好的药物释放性能和一定程度的体外经皮渗透性能。 |
| 关 键 词： | 氢溴酸加兰他敏 贴剂 释放度 经皮渗透 |
Study of the release and transdermal permeation of the transdermal patch of galanthamine hydrobromide in vitro |
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| DENG Wei-jie,ZHANG Chun-feng,ZHAO Shu-jin,LUO Jia-bo. Study of the release and transdermal permeation of the transdermal patch of galanthamine hydrobromide in vitro[J]. Academic Journal of Guangdong College of Pharmacy, 2009, 25(3): 237-241 | |
| Authors: | DENG Wei-jie ZHANG Chun-feng ZHAO Shu-jin LUO Jia-bo |
| Affiliation: | DENG Wei-jie1,ZHANG Chun-feng2,ZHAO Shu-jin1,LUO Jia-bo3 (1.Department of Pharmacy,Guangzhou General Hospital of Guangzhou Military Command,Guangzhou,Guangdong 510010,China,2.Department of Chinese Medicine,China Pharmaceutical University,Nanjing,Jiangsu 211198,3.College of Traditional Chinese Medicine,Southern Medical University,Guangdong 510515,China) |
| Abstract: | Objective To study the release and transdermal permeation of the transdermal patch of galanthamine hydrobromide in vitro.Methods The release of the transdermal patch of galanthamine hydrobromide was determined by Franz diffusion cells and first-derivative spectrophotometry.The permeation across porcine skin in vitro was studied by Franz diffusion cells and HPLC.Results The cumulative releases of the patches in 24 h(1.7 mg/cm2) were all larger than 95%,the release curve was fitted with Higuchi equation,and t... |
| Keywords: | galanthamine hydrobromide patches release rate transdermal permeation |
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