水黄皮根乙醇提取物的抗炎镇痛作用及其急性毒性的实验研究（英文）

目的：研究水黄皮根乙醇提取物的抗炎镇痛作用及其急性毒性。方法：抗炎实验采用二甲苯致小鼠耳肿胀法及大鼠棉球肉芽肿法；镇痛实验采用小鼠热板和醋酸扭体实验；采用Bliss法测定了其半数致死量（LD50）。结果：PRE可明显抑制二甲苯所致小鼠耳廓的肿胀度，抑制大鼠棉球肉芽肿的增长；可明显对抗醋酸所致小鼠的扭体次数增加，提高热板所致小鼠的痛阈值；其LD50为6．3718s／kg，LD50的95％平均可信限为5．4084～7．7232s／kg。结论：水黄皮根乙醇提取物具有明显抗炎镇痛作用，并且其急性毒性很小。

Experimental study on anti-inflammation and analgesia effect and acute toxicity of extract from Pongamia pinnata roots

AIM: To study the effect of extract from Pongamia pinnata roots on anti-inflammation and analgesia and acute toxicity. METHODS: The models of mice ear edema induced by xylene and Cotton pellet granuloma in rats to observe the anti-inflammation effect of PRE via oral administration.The effect of PRE on analgesia was tested by measuring the latent period licking hind foot with the hot plate method and counting body twisting induced by acetic acid in mice.The acute toxicity of PRE was measured by the method of Bliss. RESULTS: PRE could significantly inhibit the ear edema caused by xylene in mice,granuloma hyperplasia caused by cotton in rats.It could significantly prolong the pain threshold on hot-plate in mice,reduce the writhing times in mice.The LD_(50) of PRE was 6.371 8 g/kg,its 95% confident limit was 5.408 4-7.723 2 g/kg.CONCLUSION: PRE has obvious effect on anti-inflammation and analgesia and the lower acute toxicity.