| IMMUNOHISTOCHEMICAL STUDY OF SIXTEEN CASES OF CHORDOMA |
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| 作者姓名： | 杨践 陈志让 施达仁 |
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| 作者单位： | Raijing Hospital，Shanghai Second Medical University，Shanghai 200025 Cancer Hospital，Shanghai Medical University，Shanghai 200032 |
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| 摘 要： | ＩＭＭＵＮＯＨＩＳＴＯＣＨＥＭＩＣＡＬＳＴＵＤＹＯＦＳＩＸＴＥＥＮＣＡＳＥＳＯＦＣＨＯＲＤＯＭＡＹａｎｇＪｉａｎ；杨践；ＣｈｅｎＺｈｉｒａｎｇ；陈志让；ＳｈｉＤａｒｅｎ；施达仁（ＲａｉｊｉｎｇＨｏｓｐｉｔａｌ，ＳｈａｎｇｈａｉＳｅｃｏｎｄＭｅｄｉｃａ...
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| 修稿时间： | 23 March 1994 |
Immunohistochemical study of sixteen cases of chordoma |
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| Yang Jian,Chen Zhirang,Shi Daren.IMMUNOHISTOCHEMICAL STUDY OF SIXTEEN CASES OF CHORDOMA[J].Chinese Journal of Cancer Research,1994,6(3):208-210. |
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| Authors: | Yang Jian Chen Zhirang Shi Daren |
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| Institution: | (1) Raijing Hospital, Shanghai Second Medical University, 200025 Shanghai;(2) Cancer Hospital, Shanghai Medical University, 200032 Shanghai |
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| Abstract: | Sixteen cases of chordoms were studied with various polycolonal and monoilonal antibodies and ABC technic, such as antibodies
S-100 protein, neurou specific enodas (NSE), lysozyme, α1-AT, Myoglobin, desmin, keratin and cytokeratin. Two embryonic notochords and three chondrosarcomas were studied as control.
Most of chordomas revealed positive results with NSE (12/16), Des (12/16), α1-AT (11/16), MG (11/16), S-100 (10/16) and CK (8/16), while K and Lys were negative in all (16) cases. It denotes that chordoma
has the potentiality for both mesodermal and ectodermal differentiation. Lys was positive in all 3 chondrosarcomas while the
CK was negative. So that Lys can be considered as an useful antibody to distinguish chordoma from chondrosarcoma, and CK is
somewhat useful for this differential diagnosis too. |
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| Keywords: | Chordoma Chondrosarcoma Immunohistochemical method Lys CK |
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