| 食管癌组织中肝素酶mRNA的表达 |
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| 引用本文： | 陈奎生,唐琳,张云汉,阎亮,高冬玲,张蕾,郑湘予.食管癌组织中肝素酶mRNA的表达[J].郑州大学学报(医学版),2004,39(2):179-181. |
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| 作者姓名： | 陈奎生 唐琳 张云汉 阎亮 高冬玲 张蕾 郑湘予 |
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| 作者单位： | 河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052 |
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| 基金项目： | 河南省自然科学基金资助项目 0311643700,河南省高校青年骨干教师资助项目,“十五”“211工程”重点学科建设项目 教重办(2002)第2号 |
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| 摘 要： | 目的:探讨肝素酶mRNA表达与食管癌转移的关系。方法:采用原位杂交技术检测了54例食管鳞癌、癌旁组织及其正常食管组织中肝素酶mRNA的表达。结果:21例有淋巴结转移的食管鳞癌癌组织、癌旁及正常组织中肝素酶mRNA阳性表达率分别为100％(21/21)、66.7％(14/21)和0％(0/21)。而在无淋巴结转移的33例食管鳞癌癌组织、癌旁及正常食管组织中肝素酶mRNA阳性表达率分别为30.3％(10/33)、24.2％(8/33)和0%(0/33)。2组癌组织、癌旁组织肝素酶mRNA阳性表达率差异有统计学意义(P<0.01)。结论:肝素酶mRNA表达与食管鳞癌转移有一定关系。
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| 关 键 词： | 食管肿瘤 癌 肝索酶 |
| 修稿时间： | 2003年10月22 |
Relation between heparanase mRNA expression and metastasis of esophageal carcinoma |
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| CHEN Kuisheng,TANG Lin,ZHANG Yunhan,YAN Liang,GAO Dangling,ZHANG Lei,ZHENG Xiangyu Henan Key Laboratory of Tumor Pathology.Relation between heparanase mRNA expression and metastasis of esophageal carcinoma[J].Journal of Zhengzhou University: Med Sci,2004,39(2):179-181. |
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| Authors: | CHEN Kuisheng TANG Lin ZHANG Yunhan YAN Liang GAO Dangling ZHANG Lei ZHENG Xiangyu Henan Key Laboratory of Tumor Pathology |
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| Institution: | CHEN Kuisheng,TANG Lin,ZHANG Yunhan,YAN Liang,GAO Dangling,ZHANG Lei,ZHENG Xiangyu Henan Key Laboratory of Tumor Pathology,Department of Pathology,the First Affiliated Hospital,Zheng-zhou University,Zhengzhou 450052 |
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| Abstract: | Aim :To investigate the relation between the mRNA expression of heparanase and the metastasis of esophageal carcinoma. Methods: The expression of heparanase mRNA in 54 cases esophageal cancer including cancerous tissues, mucosa adjacent to cancer,and normal mucosa was detected by in situ hybridization. Results: The positive rates of heparanase mRNA in cancerous tissues, mucosa adjacent to cancer, and normal tissues of cases with lymph node metastasis were 100% (21/21) , 66. 7% ( 14/21 ) , and 0% , respectirely, and the positive rates of heparanase mRNA in cancerous tissues, mucosa adjacent to cancer, and normal tissues of cases without lymph node metastasis were 30. 3% (10/33) , 24. 2% (8/33) and 0% , respectirely. There was significant difference between esophageal carcinoma with lymph node metastasis and esophageal carcinoma without lymph node metastasis (P < 0. 01). Conclusion : The results suggest the expression of heparanase gene may be related to the metastasis of esophageal carcinoma. |
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| Keywords: | esophageal neoplasm carcinoma heparanase |
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