荜茇胡椒碱致畸试验研究

目的：了解蒙药荜茇降血脂有效成分胡椒碱对Wistar孕鼠的影响。方法：妊娠的雌性Wistar大鼠随机分成阴、阳性组及高、中、低剂量组每组12只,称重和编号。孕鼠于妊娠第7～16d分别灌胃胡椒碱（高剂量287.04mg/kg、中剂量71.76mg/kg、低剂量17.94mg/kg）,阳性对照组于孕期11d一次腹腔注射环磷酰胺,于妊娠第20天处死。分析胚胎发育指标,检查有无外观畸形和骨骼畸形。结果与阴性对照组比较,胡椒碱高、中剂量组对孕鼠体重增长及胎鼠生长指标有显著性差异（P〈0.05）;高剂量组对胚胎吸收率有显著性差异（P〈0.05）;胎鼠外观畸形和骨骼畸形未见显著增加。结论：本实验剂量与条件下荜茇胡椒碱高、中剂量组使孕鼠体重增长、胎鼠生长指标缓慢或下降;高剂量组有胚胎吸收的影响;低剂量组没有显著影响。对胎鼠外观、骨骼和内脏均无显著影响。

Teratogenicity of Pepper Alkali

We studied the safety of the natural effective component Pepper alkali in Piper longum L. In this study, gravid female rats were randomly divided into five groups, with 12rats in each group. They were weighed and tagged. Wister rats were irrigated with different dosages of Pepper alkali turbid liquid (high dosage 287.84mg/kg, medium Dosage 71.76mg/kg, and low dosage 17.94mg/kg) from the 7th to the 16th day of the gestation. In the positive group, cyclopsosPhamide was administered intra peritoneal on the 11t...