| 多发性骨髓瘤细胞体内生长特性的实验研究 |
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| 引用本文： | 濮翔科 邓忠彬 朱伟 薛智谋. 多发性骨髓瘤细胞体内生长特性的实验研究[J]. 实用医技杂志, 2007, 14(22): 2964-2965 |
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| 作者姓名： | 濮翔科 邓忠彬 朱伟 薛智谋 |
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| 作者单位： | [1]常州市第三人民医院,江苏常州213001 [2]苏州大学动物实验中心,江苏苏州215000 [3]苏州大学生物技术研究所,江苏苏州215000 |
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| 摘 要： | 目的:为建立人多发性骨髓瘤(Multiple Myeloma,MM)荷瘤SCID小鼠模型,研究人多发性骨髓瘤在SCID小鼠体内生长的特性。方法:体外培养IL-6依赖的人MM细胞株XG7,接种于SCID小鼠皮下;观察肿瘤生长状态,通过流式细胞技术监测肿瘤细胞表型。结果:成瘤后的肿瘤细胞CD28、CD138等分子的表达与接种前没有明显变化。结论:通过研究人MM细胞的体内生长特性可为MM的治疗奠定良好的基础。
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| 关 键 词： | 多发性骨髓瘤 SCID小鼠 研究 |
| 文章编号： | 1671-5098（2007）22-2964-02 |
| 收稿时间： | 2007-05-28 |
Experimental Research of Vivo Growth Characteristics of Human MM Cells |
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| Pu Xiang-ke, Deng Zhong-bin, Zhu Wei, Xue Zhi-mou. Experimental Research of Vivo Growth Characteristics of Human MM Cells[J]. Journal of Practical Medical Techniques, 2007, 14(22): 2964-2965 |
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| Authors: | Pu Xiang-ke Deng Zhong-bin Zhu Wei Xue Zhi-mou |
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| Abstract: | Objective:For the establishment of human multiple myeloma(Multiple Myeloma.MM)tumor model in SCID mice,vivo growth characteristics of multiple myeloma in SCID mice were studied.Methods:MM cell lines XG7 depended on IL-6 were cultivated in vitro,then cells were collected to be inoculated below the skin of SCID mice;tumorigenic state and phenotype of tumor cells were observed by flow cytometry.Results:The results showed that the expression of molecular makers of the tumor cell such as CD28 and CD138 had no significant changes before inoculation.Conclusion:So the study of vivo growth characteristics of human MM cells plays an important role in the cure of MM. |
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| Keywords: | Multiple Myeloma(MM) SCID mouse Study |
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