Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis |
| |
Authors: | Nehal N Mehta Ron Li Parasuram Krishnamoorthy Yiding Yu William Farver Amrith Rodrigues Anna Raper Mackenzie Wilcox Amanda Baer Stephanie Derohannesian Megan Wolfe Muredach P Reilly Daniel J Rader Abby Vanvoorhees Joel M Gelfand |
| |
Institution: | Cardiovascular Institute, University of Pennsylvania School of Medicine, USA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, USA. |
| |
Abstract: | ObjectivesPsoriasis is a Th-1/17 mediated inflammatory disease associated with increased risk of cardiovascular disease (CVD). Inflammation may modulate lipoprotein particle number and directly impair HDL functions, in particular reverse cholesterol transport (RCT). We sought to study how chronic in vivo inflammation modulates lipoprotein particle composition using nuclear magnetic resonance spectroscopy (NMR) and HDL efflux in psoriasis.Methods and resultsWe prospectively enrolled a consecutive sample of patients with psoriasis (n = 122) and compared lipoprotein and metabolic risk factors to patients without psoriasis (n = 134). Fasting lipids, insulin, glucose were measured by standard assays, and lipoprotein concentration and size were measured by NMR. In a random subset (n = 100 each group), HDL efflux capacity was quantified using a validated ex vivo system involving the incubation of macrophages with apolipoprotein B-depleted serum from patients. Traditional lipid concentrations were similar in both groups except for HDL concentration which was lower in psoriasis (43 mg/dl (36–58) vs 50 (42–62), p < 0.01). However, NMR showed an atherogenic profile in psoriasis similar to that observed in diabetes, with significant increase in LDL particle concentration 1210.5 (1002–1498) vs 1115 (935–1291), p = 0.02] with decrease in LDL size 20.6 (20.3–21.1) vs 21.3 (20.6–21.1), p < 0.001] beyond CV risk factors and HOMA-IR (p = 0.001). Finally, HDL efflux capacity was lower in psoriasis compared to controls in fully adjusted models (beta ?0.14, p = 0.001).ConclusionsThese data support a more atherogenic lipoprotein profile by NMR and decreased HDL efflux capacity in psoriasis patients compared to controls beyond CVD risk factors. The abnormal lipoprotein particle composition and HDL efflux capacity in psoriasis may provide a link between psoriasis and CVD. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|