三维医学影像分析系统上气道建模在儿童阻塞性睡眠呼吸暂停低通气综合征研究中应用的初探

目的　探讨三维医学影像分析系统（3D medicalimage analysis，3DMIA）软件在阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患儿上气道建模中的应用前景。方法  30例经多导睡眠监测确诊OSAHS患儿，分别于睡眠和清醒时通过螺旋CT采集资料，借助3DMIA软件构建患儿自鼻咽到声门上整个上呼吸道的三维模型，并借助软件算法进行上气道容积、气道最小横截面积的测量。结果　30例患儿睡眠时的上气道容积和气道横截面积均明显小于清醒时，其差异有显著统计学意义（t =9.392、9.256，P 均＜0.01）。结论　借助3DMIA软件建模并进行算法测量较传统放射学方法，能更客观的评价OSAHS患儿的上气道狭窄范围和程度，在OSAHS患儿的上气道形态和功能研究方面具有较好的应用前景。

Preliminary study on the application of upper-airway model construction with 3DMIA in children with OSAHS

OBJECTIVE To investigate the applicability of 3DMIA software to upper airway modeling in children with obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS A total of 30 children diagnosed with OSAHS by polysomnography were included in this study. Data regarding upper airway structure were collected via spiral CT while sleeping and awake, from which a three-dimensional model of the upper respiratory tract from the nasopharynx to the supraglottic region using 3DMIA software was constructed. The upper airway volume and airway minimum cross-sectional area were measured employing software algorithms. RESULTS The upper airway volume and airway minimum cross-sectional area of the 30 children during sleep were significantly less than those while awake (P<0.01). CONCLUSION 3DMIA software modeling and software algorithm measurement are more objective than traditional radiology (e.g. Fujioka) with respect to evaluation of the extent of the upper airway narrowing in OSAHS children, and has good applicability to study upper airway morphology and function in children with OSAHS.