阻塞性睡眠呼吸暂停低通气综合征患者上气道MRI测量值与其病情严重程度的相关性研究

目的：研究阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者清醒状态下的上气道MRI测量值与其病情严重程度评价指标的相关性，并评估其临床意义。方法对37例OSAHS患者及18例正常人进行清醒状态下上气道的MRI扫描，并对咽腔相关参数进行测量，比较OSAHS患者及正常人上气道结构的差异。并将咽腔测量参数与OSAHS严重程度评价指标（呼吸暂停低通气指数、最低血氧饱和度、氧减饱和度指数）进行相关性研究。结果 OSAHS患者软腭后区气道截面积及左右径、咽侧壁长度、舌体长度、舌根宽度、软腭长度、软腭厚度及软腭在正中矢状位的截面的面积与呼吸暂停低通气指数、最低血氧饱和度及氧减饱和度指数具有相关性（P均＜0.05）。结论上气道MRI扫描所获得的形态学测量数据可在一定程度上评估OSAHS的严重程度，对判定阻塞平面及选择治疗方案具有重要的指导意义。

Correlation between upper airway MRI parameters and the severity of patients with obstructive sleep apnea hypopnea syndrome

[ABSTRACT]OBJECTIVETo investigate the relationship between upper airway MRI parameters and the severity of patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Then the values of upper airway MRI parameters in waking state were assessed.METHODS The MRI upper airway parameters of 37 OSAHS patients and 18 nonsnoring normal subjects were measured and compared. Then data analysis were carried out to find out significant correlations between the MRI upper airway parameters and the severity of patients (the apnea hypopnea index, AHI; the lowest oxygen saturation, LSaO2; the oxygen desaturation index, ODI) with OSAHS.RESULTSThe correlation between cross-sectional areas and left-right diameter in the narrowest retropalatal region, the thickness of lateral pharyngeal wall, the length of the tongue, the length and thickness of the soft palate and the cross-sectional areas of the soft palate on midsagittal planes and severity of OSAHS were found (P<0.05).CONCLUSIONThe MRI upper airway parameters can be used in evaluating the severity of OSAHS in some ways, locating the obstruction sites and choosing the best treatment planning.