黄体酮联合寿胎丸加减治疗复发性流产

目的：观察黄体酮联合寿胎丸治疗封闭抗体阴性复发性流产疗效。方法：将2012年1月至2014年1月在我院门诊或住院治疗的200例封闭抗体阴性复发性流产患者随机分为对照组（n=100）和治疗组（n=100）。对照组为传统保胎治疗，肌注HCG、黄体酮，治疗组采用黄体酮合寿胎丸中药汤剂口服，治疗16周后进行疗效统计分析，对比2组妊娠成功率及封闭抗体转阳率。结果：治疗组妊娠成功76例，妊娠成功率为76%，对照组妊娠成功52例，成功率为52%，两者比较有显著统计学意义（P<0.05）；封闭抗体转阳率方面，治疗组转阳69例，转阳率为69%，治疗组转阳58例，转阳率58%，2组比较有显著统计学意义(P<0.O5)。结论：黄体酮联合寿胎丸治疗封闭抗体阴性复发性流产疗效确切，能明显提高妊娠成功率、封闭抗体转阳率，无不良反应，治疗成本低廉，值得临床推广及进一步研究。

Progesterone Combined with Shoutai Pill in the Treatment of Recurrent Spontaneous Abortion Associated with Blocking Antibody Negative

To observe the curative effect of progesterone combined with Shoutai Pill in the treatment of recurrent spontaneous abortion associated with negative blocking antibody. Methods: To randomly divide outpatients and inpatients who seek treatment for recurrent spontaneous abortion of negative blocking antibody type in our hospital (from January of 2012 to January of 2014) into control group (n=100) and treatment group (n=100). Traditional tocolytic therapy as intramuscular injection of HCG and progesterone was given to the control group. By contrast, progesterone combined with ShouTaiWan decoction was given to the treatment group. After 16 weeks of treatment, the success rate and conversion rate of blocking antibodies negative were compared. Results: Pregnancy success rate was 76% (76 cases) in the treatment group and 52% (52 cases) in the control group. Both of the results were of statistical significance (P<0.05). As to the blocking antibody positive conversion rate, the treatment group was 69% (69 cases) and the control group was 58% (58 cases), and both were of statistical significance (P<0.05). Conclusion: Progesterone combined with Shoutai Pill in the treatment of blocking antibody negative recurrent abortion is of obvious efficacy and can significantly improve the success rate of pregnancy and the conversion rate of antibodies. No adverse reaction has manifested. With a low treatment cost, the treatment of progesterone combined with Shoutai Pill is worth clinical promotion and further research.