Fibrinogen and Its Oxidized Form Induce Interleukin-2 Production in Cultured Endothelial Cells of Human Vessels |
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| Authors: | O. A. Azizova E. V. Maksyanina Yu. A. Romanov A. V. Aseichev O. N. Scheglovitova |
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| Affiliation: | Laboratory for Biophysical Bases of Pathology, Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow. oazizova@mail.ru |
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| Abstract: | Oxidized fibrinogen was more potent than native fibrinogen in inducing interleukin-8 production in primary culture of human endothelial cells. The optimal concentration of oxidized fibrinogen was 3 mg/ml. The optimal time of UV irradiation was 17 min. Secretion of interleukin-8 was maximum during culturing of endothelial cells in a serum-free medium. |
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| Keywords: | oxidized fibrinogen interleukin-8 culture of vascular endothelium |
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