Primär- und Rezidivtherapie des Ovarialkarzinoms

In most cases, ovarian cancer is diagnosed at an advanced stage because effective screening procedures are lacking. After adequate surgery and chemotherapy, cure is often possible in early ovarian cancer. In advanced ovarian cancer, most patients will relapse despite maximum surgery and chemotherapy. Combination chemotherapy has no advantage compared with monotherapy in so-called platinum-refractory ovarian cancer. In platinum-sensitive recurrent ovarian cancer, secondary surgery with the aim of complete resection could be beneficial in selected patients. Platinum-based combination chemotherapies are superior to monotherapy in such patients. Different toxicity profiles must be considered.