Temporäre Implantate für die endovaskuläre Applikation

Although vascular intervention using metal stents has become the gold standard of care for stenotic vessels, the lifelong persistence of metal stents within the arteries might induce long-term effects, bearing the risk of late thrombosis finally resulting in neointimal hyperplasia. However, since the vessel wall may undergo positive remodeling after stenting, the need for mechanical scaffolding of an artery may be only temporary. Thus, the use of biodegradable devices, which eventually degrade and leave only the remodeled vessel, might decrease restenosis rates. Polymeric biodegradable polylactide stents have demonstrated this potential as an alternative to standard metal stents, but to date, the human experiences with these devices are limited. The aim of this study was therefore to summarize our experiences in dealing with a biodegradable slotted tube stent made of poly-L-lactide (PLLA) with incorporation of Sirolimus (polymeric drug eluting stent).