阿司匹林联合氯吡格雷治疗进展性脑梗死的疗效观察

目的观察阿司匹林联合氯吡格雷治疗进展性脑梗死的临床疗效。方法将116例进展性脑梗死患者随机分为治疗组58例和对照组58例。2组均采用脑梗死常规治疗,治疗组给予氯吡格雷75mg和阿司匹林300mg,1次/d,连续7d,7d后改为阿司匹林300mg,1次/d,连续7d。对照组单用阿司匹林300mg,1次/d,连续14d。治疗前和治疗14d、30d后进行神经功能缺损程度评分(NIHSS评分),同时评估出血风险。结果治疗组治疗14d和30d后神经缺损评分明显优于对照组,差异有统计学意义。治疗30d后,冶疗组总有效率(89.7%)明显高于对照组(72.4%),差异有统计学意义(P0.05)。2组血小板计数、凝血指标治疗前后对比差异均无统计学意义(P0.05),2组的不良反应发生率无明显差异(P0.05)。结论短期阿司匹林联合氯吡格雷治疗进展性脑梗死可阻止病情进展,降低患者的致残率,且不会增加出血的风险。

Observation the effects of aspirin combined with clopidogrel on the treatment of progressive cerebral infarction

Objective To observe the effects of aspirin plus clopidogrel on the treatment of progressive cerebral infarction. Methods Totally patients with progressive cerebral infarction were randomly divided into two groups.Both two groups were trea-ted normal therapy of cerebral infarction.The observation group received 300 mg aspirin and 75 mg clopidogrel,once a day for 7 days and then continuously took aspirin 300 mg,one time a day.The control group took 300 mg aspirin,once a day for 14 days.Be-fore treatment and 14 days and 30 days after the treatment,the National Institutes of Health Stroke Scale(NIHSS)scores and bleeding risk were evaluated.Results 14 days and 30 days after the treatment,the NIHSS scores of the observation group were obviously better than those of the control group,with statistical difference(P <0.05).The total effective rate of observation group was 89.7% and control group was 72.4%,and the difference was significant(P <0.05 ).There were no statistical differences in platelet count and coagulation indicators in two groups before and after treatment(P >0.05).The adverse events showed no statis-tical difference between two groups(P > 0.05 ).Conclusion Short-term aspirin combined with clopidogrel therapy may have a good therapeutic effect on patients with progressive cerebral infarction,which can safely delay the progress of the disease,reduce morbidity,and not increase the nsk of bleeding.