胼胝体和扣带回弥散张量成像改变对皮质下缺血性血管性痴呆患者认知功能障碍的影响

目的应用磁共振弥散张量成像(DTI)技术,探讨皮质下缺血性血管性痴呆(SIVD)患者胼胝体和扣带回弥散张量参数改变与认知功能的关系。方法对60例SIVD患者和40例年龄匹配的非痴呆对照者,采用测定感兴趣区弥散张量参数的方法,比较其纤维束完整性差异及与MMSE的关系。结果 (1)与对照组比较,SIVD组胼胝体膝部、双侧扣带回的FA值显著下降及ADC值显著升高,而胼胝体压部的FA值和ADC值无显著性差异。(2)胼胝体膝部、双侧扣带回的FA值与MMSE评分呈明显正相关。结论胼胝体和扣带回弥散张量改变有助于SIVD患者认知功能障碍的早期预测。

Effectof MR diffusion tensor imaging in subcortical ischemic vascular dementia with cognitive impairment on corpus callousm and cingulate bundles

Objective To investigate the abnormality of association fiber tracts in corpus callousm and cingulate bundles using diffusion tensor imaging (DTI) to detect the relationship between the DTI parameters and cognitive status in subcortical ischemic vascular dementia (SIVD).Methods A region of interest-based DTI approach was applied to explore fiber tract differences and neuropsychological assessments between 60 SIVD patients and 40 matched nondemented normal aging.Results Compared with control group,SIVD had significant lower FA and greater ADC in the genu of corpus callosum,bilateral cingulate bundles,while the splenium of corpus callosum had no significant difference.Significant positively correlation was found between MMSE and the FA value of bilateral cingulate bundles and the genu of corpus callosum.Conclusion The changes of DTI parameters in corpus callousm and cingulate bundles may predict the cognitive impairment of SIVD.