Blood dendritic cells in patients with acute lymphoblastic leukaemia |
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Authors: | Mami Naira Ben Mohty Mohamad Chambost Hervé Gaugler Béatrice Olive Daniel |
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Institution: | Laboratoire d'Immunologie des Tumeurs, Institut Paoli-Calmettes, Université de la Méditerranée, 232 Bd. Ste. Marguerite, 13273 Marseille Cedex 09, France. |
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Abstract: | Myeloid and plasmacytoid dendritic cells (MDCs, PDCs) play a key role in the initiation of immune responses. In this study, we show a severe reduction of MDCs and PDCs in patients with B lineage acute lymphoblastic leukaemia (B-ALL; P = 0.01 vs. controls). DCs from patients with T lineage ALL (T-ALL) were quantitatively and functionally comparable to healthy donors, as demonstrated by secretion of interleukin (IL)-12p70 and interferon-alpha. In vitro, the circulating CD34(+) fraction of B-ALL cases did not generate either CD1a(+) MDCs or PDCs, suggesting that DC development is probably affected in B-ALL, but not in T-ALL. |
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Keywords: | acute lymphoblastic leukaemia dendritic cell haematopoiesis interferon-α immunotherapy |
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