壳聚糖对大鼠胃损伤时黏膜的保护作用

目的研究壳聚糖对大鼠急性损伤时胃黏膜的保护作用。方法采用幽门结扎法建立大鼠损伤模型,然后收集胃液、胃损伤指数计分及SP免疫组化法实验。结果与对照组比较,实验组黏膜损伤指数显著下降(P<0.001);胃内游离酸和总酸度显著降低(P<0.05);诱导型一氧化氮合酶(iNOS)表达显著升高(P<0.01)。结论壳聚糖处理可明显减轻大鼠幽门结扎所致的胃黏膜损伤,对胃黏膜具有很好的保护作用。

Protection of chitosan on gastric mucosal acute injury in rats

Purpose To demonstrate the protective effect of the chitosan pretreatment on function of gastric acid secretion in acute gastric mucosal injury in rats.Methods Useing the method of ligating pylorus to establish the injured rats model and comparing with the control group.Results The mucosal injury indexes of the chitosan group are significantly lower than those of the control group(P<0.001).The free acidity and total acidity in stomach of the chitosan group are significantly lower than those of the control group(P<0.05).The expression of iNOS of the chitosan group is significantly higher than that of the control group(P<0.01).Conclusion The chitosan can significantly alleviate the injury of gastric mucosa which results from ligating pylorus of the rats,and also has the protective effect on the gastric mucosa.