妊高征患者血浆心钠素水平及与血液流变学的关系

测定了正常孕妇和妊高征患者不同孕期的血浆心钠素水平，观察了妊高征患者血浆心钠素水平与血液流变学和病情的关系。结果表明，正常孕妇在妊娠早、中期心钠素水平与非孕妇女无差异，至妊娠晚期明显提高，妊高征患者心钠素水平明显高于非孕妇女和正常孕妇，血液浓缩、血流变减退的妊高征患者心钠素水平低于无血液浓缩者，重度妊高征患者心钠素水平高于轻、中度者，妊高征心钠素水平与血流变学指标呈负相关，与平均动脉压呈正相关，提示妊高征患者心钠素水平主重受血容量和血压的调控，并且与病情的严重程度有关。心钠素可能参与了妊高征的发病过程。

Plasma atrial natriuretic peptide concentration in pregenacyinduced hypertension and its relation ship with blood viscosity

Plasma atrial natriuretic peptide (ANP)concentration in normal pregnant women, pregnancy-induced hypertension (PIH)patients and non-pregnant controls was determined, the relationships between ANP concentration end blood viscosity or severity of PIH were observed.There was no difference among ANP concentrations of non-pregnant controls, normal pregnant women during first and second trimester, but it increased significantly during third trimester. PIH women had significantly higher ANP level than that in non-pregnant controls and normal pregnant women. ANP concentration of PIH patients with high blood viscosity.was relatively lower than that of patients with normal blood viscosity, and ANP concentration of servere PIH women was relatively higher than that of mild-middle PIH women. ANP concentration in PIH women was related negative to blood viscosity, but positive to mean blood pressure, significantly.The results indicate that blood volume and blood pressure regulate plasma ANP concentration in PIH women, ANP may be responsible for the development of PIH and may serve as an indicator of severity of PIH.